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    GPAT2 glycerol-3-phosphate acyltransferase 2, mitochondrial [ Homo sapiens (human) ]

    Gene ID: 150763, updated on 27-Dec-2024

    Summary

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    Official Symbol
    GPAT2provided by HGNC
    Official Full Name
    glycerol-3-phosphate acyltransferase 2, mitochondrialprovided by HGNC
    Primary source
    HGNC:HGNC:27168
    See related
    Ensembl:ENSG00000186281 MIM:616431; AllianceGenome:HGNC:27168
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CT123
    Summary
    Enables glycerol-3-phosphate O-acyltransferase activity. Predicted to be involved in glycerol-3-phosphate metabolic process; glycerolipid biosynthetic process; and piRNA processing. Located in mitochondrion. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in testis (RPKM 7.1), spleen (RPKM 3.6) and 22 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See GPAT2 in Genome Data Viewer
    Location:
    2q11.2
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (96021946..96036265, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (95919725..96542891, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (96687694..96702013, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene RNA, 7SL, cytoplasmic 210, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:96675379-96676210 Neighboring gene fumarylacetoacetate hydrolase domain-containing protein 2B-like Neighboring gene fumarylacetoacetate hydrolase domain containing 2C, pseudogene Neighboring gene uncharacterized LOC105373494 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:96725007-96725917 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:96757989-96758504 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:96774519-96775506 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11747 Neighboring gene adrenoceptor alpha 2B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. Glycerol-3-phosphate acyltranferase-2 behaves as a cancer testis gene and promotes growth and tumorigenicity of the breast cancer MDA-MB-231 cell line. Pellon-Maison M, et al. PLoS One, 2014. PMID 24967918, Free PMC Article
    2. Thematic review series: glycerolipids. Mammalian glycerol-3-phosphate acyltransferases: new genes for an old activity. Gimeno RE, et al. J Lipid Res, 2008 Oct. PMID 18658143
    3. Cloning and functional characterization of a novel mitochondrial N-ethylmaleimide-sensitive glycerol-3-phosphate acyltransferase (GPAT2). Wang S, et al. Arch Biochem Biophys, 2007 Sep 15. PMID 17689486, Free PMC Article
    4. GPAT2, a mitochondrial outer membrane protein, in piRNA biogenesis in germline stem cells. Shiromoto Y, et al. RNA, 2013 Jun. PMID 23611983, Free PMC Article
    5. AGPAT6 is a novel microsomal glycerol-3-phosphate acyltransferase. Chen YQ, et al. J Biol Chem, 2008 Apr 11. PMID 18238778, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. GPAT2 as a cancer testis gene
      Title: Glycerol-3-phosphate acyltranferase-2 behaves as a cancer testis gene and promotes growth and tumorigenicity of the breast cancer MDA-MB-231 cell line.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Replication interactions

    Interaction Pubs
    Knockdown of glycerol-3-phosphate acyltransferase 2, mitochondrial (GPAT2) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables 1-acylglycerol-3-phosphate O-acyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables glycerol-3-phosphate O-acyltransferase activity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables glycerol-3-phosphate O-acyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glycerol-3-phosphate O-acyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in CDP-diacylglycerol biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glycerol-3-phosphate metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in glycerophospholipid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phosphatidic acid biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in phosphatidic acid biosynthetic process TAS
    Traceable Author Statement
    more info
    		  
    involved_in piRNA processing ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in triglyceride biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in triglyceride biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial outer membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in mitochondrial outer membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in mitochondrion HTP PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in mitochondrion NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    glycerol-3-phosphate acyltransferase 2, mitochondrial
    Names
    1-acylglycerol-3-phosphate O-acyltransferase GPAT2
    cancer/testis antigen 123
    NP_001308454.1
    NP_001308455.1
    NP_001308456.1
    NP_001308457.1
    NP_001308458.1
    NP_001308459.1
    NP_001308460.1
    NP_001376568.1
    NP_997211.2
    XP_016858913.1
    XP_047299417.1
    XP_047299418.1
    XP_047299419.1
    XP_047299420.1
    XP_047299421.1
    XP_047299422.1
    XP_047299423.1
    XP_047299424.1
    XP_047299425.1
    XP_047299426.1
    XP_047299427.1
    XP_047299428.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001321525.2 → NP_001308454.1  glycerol-3-phosphate acyltransferase 2, mitochondrial isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC013272
      Consensus CDS
      CCDS92811.1
      UniProtKB/TrEMBL
      B4DNZ9
      Related
      ENST00000486463.5
      Conserved Domains (1) summary
      cd07993
      Location:176 → 388
      LPLAT_DHAPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like

    2. NM_001321526.2 → NP_001308455.1  glycerol-3-phosphate acyltransferase 2, mitochondrial isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC013272
      Consensus CDS
      CCDS92811.1
      UniProtKB/TrEMBL
      B4DNZ9
      Conserved Domains (1) summary
      cd07993
      Location:176 → 388
      LPLAT_DHAPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like

    3. NM_001321527.2 → NP_001308456.1  glycerol-3-phosphate acyltransferase 2, mitochondrial isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC013272
      Consensus CDS
      CCDS92811.1
      UniProtKB/TrEMBL
      B4DNZ9
      Related
      ENSP00000389395.2, ENST00000434632.6
      Conserved Domains (1) summary
      cd07993
      Location:176 → 388
      LPLAT_DHAPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like

    4. NM_001321528.2 → NP_001308457.1  glycerol-3-phosphate acyltransferase 2, mitochondrial isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC013272
      Conserved Domains (1) summary
      cd07993
      Location:176 → 388
      LPLAT_DHAPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like

    5. NM_001321529.2 → NP_001308458.1  glycerol-3-phosphate acyltransferase 2, mitochondrial isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC013272
      UniProtKB/TrEMBL
      B4DNZ9
      Conserved Domains (1) summary
      cl17185
      Location:176 → 317
      LPLAT; Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis

    6. NM_001321530.2 → NP_001308459.1  glycerol-3-phosphate acyltransferase 2, mitochondrial isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC013272
      Consensus CDS
      CCDS82482.1
      UniProtKB/TrEMBL
      B4DNZ9, E9PE95
      Related
      ENSP00000393770.1, ENST00000453542.5
      Conserved Domains (1) summary
      cl17185
      Location:176 → 317
      LPLAT; Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis

    7. NM_001321531.2 → NP_001308460.1  glycerol-3-phosphate acyltransferase 2, mitochondrial isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC013272, AK131194, BC068596
      Consensus CDS
      CCDS92810.1
      Related
      ENSP00000509192.1, ENST00000687910.1
      Conserved Domains (1) summary
      cd07993
      Location:176 → 388
      LPLAT_DHAPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like

    8. NM_001389639.1 → NP_001376568.1  glycerol-3-phosphate acyltransferase 2, mitochondrial isoform 9

      Status: VALIDATED

      Source sequence(s)
      AC013272
      Conserved Domains (1) summary
      cd07993
      Location:176 → 388
      LPLAT_DHAPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like

    9. NM_207328.4 → NP_997211.2  glycerol-3-phosphate acyltransferase 2, mitochondrial isoform 1

      See identical proteins and their annotated locations for NP_997211.2

      Status: VALIDATED

      Source sequence(s)
      AC013272
      Consensus CDS
      CCDS42714.1
      UniProtKB/Swiss-Prot
      Q6NUI2, Q6P2E4, Q6ZNI3, Q6ZNI5, Q6ZWJ4
      UniProtKB/TrEMBL
      B4DNZ9
      Related
      ENSP00000352547.4, ENST00000359548.8
      Conserved Domains (1) summary
      cd07993
      Location:176 → 388
      LPLAT_DHAPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      96021946..96036265 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047443468.1 → XP_047299424.1  glycerol-3-phosphate acyltransferase 2, mitochondrial isoform X4

      UniProtKB/Swiss-Prot
      Q6NUI2, Q6P2E4, Q6ZNI3, Q6ZNI5, Q6ZWJ4
      UniProtKB/TrEMBL
      B4DNZ9

    2. XM_047443464.1 → XP_047299420.1  glycerol-3-phosphate acyltransferase 2, mitochondrial isoform X1

    3. XM_047443466.1 → XP_047299422.1  glycerol-3-phosphate acyltransferase 2, mitochondrial isoform X4

      UniProtKB/Swiss-Prot
      Q6NUI2, Q6P2E4, Q6ZNI3, Q6ZNI5, Q6ZWJ4
      UniProtKB/TrEMBL
      B4DNZ9

    4. XM_047443462.1 → XP_047299418.1  glycerol-3-phosphate acyltransferase 2, mitochondrial isoform X1

    5. XM_047443467.1 → XP_047299423.1  glycerol-3-phosphate acyltransferase 2, mitochondrial isoform X4

      UniProtKB/Swiss-Prot
      Q6NUI2, Q6P2E4, Q6ZNI3, Q6ZNI5, Q6ZWJ4
      UniProtKB/TrEMBL
      B4DNZ9

    6. XM_017003424.2 → XP_016858913.1  glycerol-3-phosphate acyltransferase 2, mitochondrial isoform X3

      UniProtKB/TrEMBL
      B4DNZ9
      Conserved Domains (1) summary
      cd07993
      Location:176 → 388
      LPLAT_DHAPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like

    7. XM_047443463.1 → XP_047299419.1  glycerol-3-phosphate acyltransferase 2, mitochondrial isoform X1

    8. XM_047443465.1 → XP_047299421.1  glycerol-3-phosphate acyltransferase 2, mitochondrial isoform X2

    9. XM_047443461.1 → XP_047299417.1  glycerol-3-phosphate acyltransferase 2, mitochondrial isoform X1

      Related
      ENST00000484440.5

    10. XM_047443471.1 → XP_047299427.1  glycerol-3-phosphate acyltransferase 2, mitochondrial isoform X7

    11. XM_047443472.1 → XP_047299428.1  glycerol-3-phosphate acyltransferase 2, mitochondrial isoform X8

    12. XM_047443470.1 → XP_047299426.1  glycerol-3-phosphate acyltransferase 2, mitochondrial isoform X6

    13. XM_047443469.1 → XP_047299425.1  glycerol-3-phosphate acyltransferase 2, mitochondrial isoform X5

      UniProtKB/TrEMBL
      B4DNZ9

    RNA

    1. XR_007069660.1 RNA Sequence

    2. XR_007069659.1 RNA Sequence

    3. XR_007069658.1 RNA Sequence

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_025791765.1 Reference GRCh38.p14 PATCHES

      Range
      55799..58170
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      95919725..96542891 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6NUI2.2 GenPept UniProtKB/Swiss-Prot:Q6NUI2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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