SSY5 Ssy5p [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: SSY5
Official Full Name: Ssy5p
Primary source: SGD:S000003692
Locus tag: YJL156C
See related: AllianceGenome:SGD:S000003692; FungiDB:YJL156C; VEuPathDB:YJL156C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: RAA3
Summary: Enables serine-type endopeptidase activity. Involved in protein autoprocessing and response to amino acid. Located in plasma membrane. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See SSY5 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 1

Sequence:: Chromosome: X; NC_001142.9 (126853..128952, complement)

Chromosome X - NC_001142.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001142.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The Saccharomyces cerevisiae Ssy5 signaling protease (SSY5) is a core component of the plasma membrane (PM)-localized Ssy1-Ptr3-Ssy5 (SPS) sensor.
Title: Spatial and temporal regulation of the endoproteolytic activity of the SPS-sensor-controlled Ssy5 signaling protease.
Reduced Ssy1-Ptr3-Ssy5 (SPS) signaling extends replicative life span by enhancing NAD+ homeostasis in Saccharomyces cerevisiae.
Title: Reduced Ssy1-Ptr3-Ssy5 (SPS) signaling extends replicative life span by enhancing NAD+ homeostasis in Saccharomyces cerevisiae.
Rts1 constitutively directs protein phosphatase 2A activity toward the prodomain, effectively setting a signaling threshold required to mute Ssy5 activation.
Title: Rts1-protein phosphatase 2A antagonizes Ptr3-mediated activation of the signaling protease Ssy5 by casein kinase I.
A phosphodegron controls nutrient-induced proteasomal activation of the signaling protease Ssy5.
Title: A phosphodegron controls nutrient-induced proteasomal activation of the signaling protease Ssy5.
Study propose that the Ssy5 protease is activated by phosphorylation-induced ubiquitylation, the effect of which is relief from inhibition by its prodomain.
Title: Amino acid signaling in yeast: activation of Ssy5 protease is associated with its phosphorylation-induced ubiquitylation.
Differential regulation of transcription factors Stp1 and Stp2 in the Ssy1-Ptr3-Ssy5 amino acid sensing pathway.
Title: Differential regulation of transcription factors Stp1 and Stp2 in the Ssy1-Ptr3-Ssy5 amino acid sensing pathway.
Data show that the Ssy5 prodomain is a potent inhibitor of chymotrypsin-like catalytic cleavage of Stp1 and that inactivation of Ssy5 is a requisite for receptor-activated proteolysis.
Title: The prodomain of Ssy5 protease controls receptor-activated proteolysis of transcription factor Stp1.
Ssy5 is the endoprotease responsible for Stp1 processing
Title: Amino acid signaling in yeast: casein kinase I and the Ssy5 endoprotease are key determinants of endoproteolytic activation of the membrane-bound Stp1 transcription factor.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables peptidase activity	IEA Inferred from Electronic Annotation more info
enables serine-type endopeptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables serine-type endopeptidase activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in protein autoprocessing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein processing	IDA Inferred from Direct Assay more info	PubMed
involved_in protein processing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
involved_in response to amino acid	IGI Inferred from Genetic Interaction more info	PubMed
involved_in response to amino acid	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Ssy5p

NP_012379.2

Serine protease of SPS plasma membrane amino acid sensor system; contains an inhibitory domain that dissociates in response to extracellular amino acids, freeing a catalytic domain to activate transcription factor Stp1p; other members are Ssy1p and Ptr3p

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001142.9 Reference assembly

Range

126853..128952 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001181589.1 → NP_012379.2 TPA: Ssy5p [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_012379.2

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VW31, P47002

UniProtKB/TrEMBL

G2WGL7

Conserved Domains (1) summary

pfam08192
Location:1 → 693

Peptidase_S64; Peptidase family S64