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    PF3D7_1028700 merozoite TRAP-like protein [ Plasmodium falciparum 3D7 ]

    Gene ID: 810438, updated on 12-Sep-2024

    Summary

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    Gene symbol
    PF3D7_1028700
    Gene description
    merozoite TRAP-like protein
    Locus tag
    PF3D7_1028700
    See related
    PlasmoDB:PF3D7_1028700; VEuPathDB:PF3D7_1028700
    Gene type
    protein coding
    RNA name
    merozoite TRAP-like protein
    RefSeq status
    PROVISIONAL
    Organism
    Plasmodium falciparum 3D7 (isolate: 3D7)
    Lineage
    Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida; Plasmodiidae; Plasmodium; Plasmodium (Laverania)
    Orthologs
    all
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    Genomic context

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    See PF3D7_1028700 in Genome Data Viewer
    Location:
    chromosome: 10
    Exon count:
    1
    Sequence:
    Chromosome: 10; NC_037281.1 (1181005..1182501)

    Chromosome 10 - NC_037281.1Genomic Context describing neighboring genes Neighboring gene partial CSTF domain-containing protein, putative Neighboring gene conserved Plasmodium protein, unknown function Neighboring gene conserved protein, unknown function Neighboring gene inner membrane complex protein 1m, putative

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037281.1

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Plasmodium Merozoite TRAP Family Protein Is Essential for Vacuole Membrane Disruption and Gamete Egress from Erythrocytes. Bargieri DY, et al. Cell Host Microbe, 2016 Nov 9. PMID 27832590, Free PMC Article
    2. Semaphorin-7A is an erythrocyte receptor for P. falciparum merozoite-specific TRAP homolog, MTRAP. Bartholdson SJ, et al. PLoS Pathog, 2012. PMID 23166499, Free PMC Article
    3. Analysis of the conformation and function of the Plasmodium falciparum merozoite proteins MTRAP and PTRAMP. Uchime O, et al. Eukaryot Cell, 2012 May. PMID 22467743, Free PMC Article
    4. A conserved molecular motor drives cell invasion and gliding motility across malaria life cycle stages and other apicomplexan parasites. Baum J, et al. J Biol Chem, 2006 Feb 24. PMID 16321976
    5. A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, et al. Nature, 2005 Nov 3. PMID 16267556

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MTRAP is essential forplasmodium gamete egress from erythrocytes, where it is necessary for the disruption of the gamete-containing parasitophorous vacuole membrane, and thus for parasite transmission to mosquitoes.
      Title: Plasmodium Merozoite TRAP Family Protein Is Essential for Vacuole Membrane Disruption and Gamete Egress from Erythrocytes.
    2. two MTRAP monomers interact via their tandem TSR domains with the Sema domains of a Semaphorin-7A homodimer
      Title: Semaphorin-7A is an erythrocyte receptor for P. falciparum merozoite-specific TRAP homolog, MTRAP.
    3. MTRAP but not PTRAMP bound human erythrocytes. MTRAP is a highly extended bifunctional protein that binds to an erythrocyte receptor and the merozoite motor.
      Title: Analysis of the conformation and function of the Plasmodium falciparum merozoite proteins MTRAP and PTRAMP.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by GeneDB

    Function Evidence Code Pubs
    enables host cell surface receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within exit from host cell IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in microneme IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    merozoite TRAP-like protein

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_037281.1 Reference assembly

      Range
      1181005..1182501
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_001347529.1 → XP_001347565.1  merozoite TRAP-like protein [Plasmodium falciparum 3D7]

      See identical proteins and their annotated locations for XP_001347565.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A024W6T9, A0A2I0BR64, Q8IJB7, W4J2D4
    Nucleotide Protein
    Heading Accession and Version

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