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    PF3D7_1136900 subtilisin-like protease 2 [ Plasmodium falciparum 3D7 ]

    Gene ID: 810927, updated on 12-Sep-2024

    Summary

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    Gene symbol
    PF3D7_1136900
    Gene description
    subtilisin-like protease 2
    Locus tag
    PF3D7_1136900
    See related
    PlasmoDB:PF3D7_1136900; VEuPathDB:PF3D7_1136900
    Gene type
    protein coding
    RNA name
    subtilisin-like protease 2
    RefSeq status
    PROVISIONAL
    Organism
    Plasmodium falciparum 3D7 (isolate: 3D7)
    Lineage
    Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida; Plasmodiidae; Plasmodium; Plasmodium (Laverania)
    Orthologs
    all
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    Genomic context

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    See PF3D7_1136900 in Genome Data Viewer
    Location:
    chromosome: 11
    Exon count:
    2
    Sequence:
    Chromosome: 11; NC_037282.1 (1456151..1460319)

    Chromosome 11 - NC_037282.1Genomic Context describing neighboring genes Neighboring gene conserved Plasmodium protein, unknown function Neighboring gene DnaJ protein, putative Neighboring gene ncRNA Neighboring gene mitochondrial ribosomal protein S9 precursor, putative

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037282.1

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The malaria parasite sheddase SUB2 governs host red blood cell membrane sealing at invasion. Collins CR, et al. Elife, 2020 Dec 8. PMID 33287958, Free PMC Article
    2. Molecular determinants for subcellular trafficking of the malarial sheddase PfSUB2. Child MA, et al. Traffic, 2013 Oct. PMID 23834729
    3. Molecular identification of a malaria merozoite surface sheddase. Harris PK, et al. PLoS Pathog, 2005 Nov. PMID 16322767, Free PMC Article
    4. Plasmodium falciparum subtilisin-like protease 2, a merozoite candidate for the merozoite surface protein 1-42 maturase. Barale JC, et al. Proc Natl Acad Sci U S A, 1999 May 25. PMID 10339607, Free PMC Article
    5. Transcriptional activity of Plasmodium subtilisin-like protease 2 (Pf-Sub2) 5'untranslated regions and its interaction with hepatocyte growth factor. Liao S, et al. Korean J Parasitol, 2010 Dec. PMID 21234230, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PTRAMP undergoes proteolytic processing upon invasion of erythrocytes, and this processing is inhibited by the subtilisin-like protease PfSUB2
      Title: Plasmodium thrombospondin related apical merozoite protein (PTRAMP) is shed from the surface of merozoites by PfSUB2 upon invasion of erythrocytes.
    2. Taken together, it is suggested that human HGF controls and interacts with the promoter region of the Sub2 gene of Plasmodium falciparum.
      Title: Transcriptional activity of Plasmodium subtilisin-like protease 2 (Pf-Sub2) 5'untranslated regions and its interaction with hepatocyte growth factor.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by GeneDB

    Function Evidence Code Pubs
    enables serine-type peptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within protein maturation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within proteolysis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within symbiont entry into host IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in merozoite dense granule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in microneme IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in osmiophilic body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    subtilisin-like protease 2
    XP_001348051.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_037282.1 Reference assembly

      Range
      1456151..1460319
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_001348015.1 → XP_001348051.1  subtilisin-like protease 2 [Plasmodium falciparum 3D7]

      See identical proteins and their annotated locations for XP_001348051.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q8IHZ5
      UniProtKB/TrEMBL
      A0A0L1I767, W7K4R7
      Conserved Domains (2) summary
      pfam18513
      Location:554 → 640
      Pro_sub2; Prodomain subtilisin 2
      cl10459
      Location:745 → 997
      Peptidases_S8_S53; Peptidase domain in the S8 and S53 families
    Nucleotide Protein
    Heading Accession and Version

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