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    ZNF362 zinc finger protein 362 [ Homo sapiens (human) ]

    Gene ID: 149076, updated on 10-Dec-2024

    Summary

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    Official Symbol
    ZNF362provided by HGNC
    Official Full Name
    zinc finger protein 362provided by HGNC
    Primary source
    HGNC:HGNC:18079
    See related
    Ensembl:ENSG00000160094 AllianceGenome:HGNC:18079
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RN; lin-29
    Summary
    Predicted to enable DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in spleen (RPKM 4.1), kidney (RPKM 3.8) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ZNF362 in Genome Data Viewer
    Location:
    1p35.1
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (33127522..33300719)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (32987140..33162335)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (33722093..33766320)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124903969 Neighboring gene uncharacterized LOC105378635 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 615 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:33549697-33550196 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:33557899-33558556 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 706 Neighboring gene antizyme inhibitor 2 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:33592415-33593614 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 616 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:33605527-33606126 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:33606727-33607326 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:33628780-33629512 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:33629513-33630245 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_7027 Neighboring gene tripartite motif containing 62 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_7034 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_7044 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 617 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 619 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 618 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_7054 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_7061 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 620 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:33685009-33685609 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:33685744-33686528 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:33709758-33710342 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 621 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 622 Neighboring gene Sharpr-MPRA regulatory region 4113 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:33729134-33729634 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:33734235-33734736 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:33760897-33761407 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:33764372-33764552 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:33764984-33765933 Neighboring gene MPRA-validated peak168 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:33795184-33795684 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:33795685-33796185 Neighboring gene alpha 1,3-galactosyltransferase 2 Neighboring gene microRNA 3605 Neighboring gene polyhomeotic homolog 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Identification of the SOX2 Interactome by BioID Reveals EP300 as a Mediator of SOX2-dependent Squamous Differentiation and Lung Squamous Cell Carcinoma Growth. Kim BR, et al. Mol Cell Proteomics, 2017 Oct. PMID 28794006, Free PMC Article
    2. USP7 Regulates Cytokinesis through FBXO38 and KIF20B. Georges A, et al. Sci Rep, 2019 Feb 25. PMID 30804394, Free PMC Article
    3. Mutations of the Transcriptional Corepressor ZMYM2 Cause Syndromic Urinary Tract Malformations. Connaughton DM, et al. Am J Hum Genet, 2020 Oct 1. PMID 32891193, Free PMC Article
    4. Proximity-dependent Mapping of the Androgen Receptor Identifies Kruppel-like Factor 4 as a Functional Partner. Vélot L, et al. Mol Cell Proteomics, 2021. PMID 33640491, Free PMC Article
    5. Mapping the Ku Interactome Using Proximity-Dependent Biotin Identification in Human Cells. Abbasi S, et al. J Proteome Res, 2019 Mar 1. PMID 30585729

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ25476, MGC138318

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 362
    Names
    rotund homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001370212.1 → NP_001357141.1  zinc finger protein 362

      Status: VALIDATED

      Source sequence(s)
      AL513327
      Consensus CDS
      CCDS377.1
      UniProtKB/Swiss-Prot
      Q5T0B9, Q8WYU4
      Related
      ENSP00000362527.5, ENST00000373428.5
      Conserved Domains (5) summary
      COG5189
      Location:307 → 359
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      PRK14971
      Location:27 → 125
      PRK14971; DNA polymerase III subunit gamma/tau
      sd00017
      Location:257 → 277
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:255 → 277
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:269 → 294
      zf-H2C2_2; Zinc-finger double domain

    2. NM_152493.3 → NP_689706.2  zinc finger protein 362

      See identical proteins and their annotated locations for NP_689706.2

      Status: VALIDATED

      Source sequence(s)
      AF318356, AL513327, AW204855, BF743001, BX283663
      Consensus CDS
      CCDS377.1
      UniProtKB/Swiss-Prot
      Q5T0B9, Q8WYU4
      Related
      ENSP00000446335.1, ENST00000539719.6
      Conserved Domains (5) summary
      COG5189
      Location:307 → 359
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      PRK14971
      Location:27 → 125
      PRK14971; DNA polymerase III subunit gamma/tau
      sd00017
      Location:257 → 277
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:255 → 277
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:269 → 294
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      33127522..33300719
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047447108.1 → XP_047303064.1  zinc finger protein 362 isoform X1

      Conserved Domains (5) summary
      COG5189
      Location:325 → 377
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      PRK14971
      Location:45 → 143
      PRK14971; DNA polymerase III subunit gamma/tau
      sd00017
      Location:275 → 295
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:273 → 295
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:287 → 312
      zf-H2C2_2; Zinc-finger double domain

    2. XM_047447107.1 → XP_047303063.1  zinc finger protein 362 isoform X1

      Conserved Domains (5) summary
      COG5189
      Location:325 → 377
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      PRK14971
      Location:45 → 143
      PRK14971; DNA polymerase III subunit gamma/tau
      sd00017
      Location:275 → 295
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:273 → 295
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:287 → 312
      zf-H2C2_2; Zinc-finger double domain

    3. XM_047447110.1 → XP_047303066.1  zinc finger protein 362 isoform X4

    4. XM_005270507.3 → XP_005270564.1  zinc finger protein 362 isoform X3

      See identical proteins and their annotated locations for XP_005270564.1

      Conserved Domains (5) summary
      COG5189
      Location:294 → 346
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      PRK14971
      Location:14 → 112
      PRK14971; DNA polymerase III subunit gamma/tau
      sd00017
      Location:244 → 264
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:242 → 264
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:256 → 281
      zf-H2C2_2; Zinc-finger double domain

    5. XM_047447109.1 → XP_047303065.1  zinc finger protein 362 isoform X2

      UniProtKB/Swiss-Prot
      Q5T0B9, Q8WYU4

    6. XM_005270508.6 → XP_005270565.1  zinc finger protein 362 isoform X3

      See identical proteins and their annotated locations for XP_005270565.1

      Conserved Domains (5) summary
      COG5189
      Location:294 → 346
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      PRK14971
      Location:14 → 112
      PRK14971; DNA polymerase III subunit gamma/tau
      sd00017
      Location:244 → 264
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:242 → 264
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:256 → 281
      zf-H2C2_2; Zinc-finger double domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      32987140..33162335
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054334631.1 → XP_054190606.1  zinc finger protein 362 isoform X1

    2. XM_054334630.1 → XP_054190605.1  zinc finger protein 362 isoform X1

    3. XM_054334635.1 → XP_054190610.1  zinc finger protein 362 isoform X4

    4. XM_054334633.1 → XP_054190608.1  zinc finger protein 362 isoform X3

    5. XM_054334632.1 → XP_054190607.1  zinc finger protein 362 isoform X2

      UniProtKB/Swiss-Prot
      Q5T0B9, Q8WYU4

    6. XM_054334634.1 → XP_054190609.1  zinc finger protein 362 isoform X3

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5T0B9.1 GenPept UniProtKB/Swiss-Prot:Q5T0B9

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