Alkal1 ALK and LTK ligand 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Alkal1provided by MGI
Official Full Name: ALK and LTK ligand 1provided by MGI
Primary source: MGI:MGI:3645495
See related: Ensembl:ENSMUSG00000087247 AllianceGenome:MGI:3645495
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Augbeta; Fam150a; EG620393
Summary: Predicted to enable protein tyrosine kinase activator activity and signaling receptor binding activity. Predicted to be involved in cell surface receptor protein tyrosine kinase signaling pathway; positive regulation of MAPK cascade; and positive regulation of neuron projection development. Predicted to be located in plasma membrane. Predicted to be active in extracellular space. Orthologous to human ALKAL1 (ALK and LTK ligand 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in stomach adult (RPKM 1.8), lung adult (RPKM 1.1) and 4 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 A1; 1 1.89 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (6429555..6464955)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (6359331..6394731)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MerTK[+] macrophages promote melanoma progression and immunotherapy resistance through AhR-ALKAL1 activation.
Title: MerTK(+) macrophages promote melanoma progression and immunotherapy resistance through AhR-ALKAL1 activation.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cytokine activity	ISO Inferred from Sequence Orthology more info
enables cytokine activity	ISS Inferred from Sequence or Structural Similarity more info
enables receptor signaling protein tyrosine kinase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables receptor signaling protein tyrosine kinase activator activity	ISO Inferred from Sequence Orthology more info
enables receptor signaling protein tyrosine kinase activator activity	ISS Inferred from Sequence or Structural Similarity more info
enables receptor tyrosine kinase binding	IBA Inferred from Biological aspect of Ancestor more info
enables receptor tyrosine kinase binding	IEA Inferred from Electronic Annotation more info
enables receptor tyrosine kinase binding	ISO Inferred from Sequence Orthology more info
enables transmembrane receptor protein tyrosine kinase activator activity	IEA Inferred from Electronic Annotation more info
enables transmembrane receptor protein tyrosine kinase activator activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cell surface receptor protein tyrosine kinase signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in cell surface receptor protein tyrosine kinase signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ERK1 and ERK2 cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of ERK1 and ERK2 cascade	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ERK5 cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of ERK5 cascade	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of ERK5 cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron projection development	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of neuron projection development	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info
located_in extracellular space	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ALK and LTK ligand 1

Names: AUG-beta; augmentor beta; family with sequence similarity 150, member A; protein FAM150A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001195732.1 → NP_001182661.1 ALK and LTK ligand 1 precursor

Status: PROVISIONAL

Source sequence(s)

AC139064, AK087278

Consensus CDS

CCDS56620.1

UniProtKB/Swiss-Prot

J3QPP8

Related

ENSMUSP00000137420.2, ENSMUST00000133144.4

Conserved Domains (1) summary

pfam15129
Location:58 → 126

FAM150; FAM150 family