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    Ints9 integrator complex subunit 9 [ Mus musculus (house mouse) ]

    Gene ID: 210925, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ints9provided by MGI
    Official Full Name
    integrator complex subunit 9provided by MGI
    Primary source
    MGI:MGI:1098533
    See related
    Ensembl:ENSMUSG00000021975 AllianceGenome:MGI:1098533
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    D14Ertd231e
    Summary
    Predicted to be involved in negative regulation of transforming growth factor beta receptor signaling pathway and snRNA 3'-end processing. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of integrator complex. Orthologous to human INTS9 (integrator complex subunit 9). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in thymus adult (RPKM 12.8), limb E14.5 (RPKM 10.8) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ints9 in Genome Data Viewer
    Location:
    14 D1; 14 33.81 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (65187494..65277284)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (64950045..65039835)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene homeobox containing 1 Neighboring gene 60S ribosomal protein L35a pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:65534306-65534489 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:65568546-65568932 Neighboring gene high mobility group nucleosomal binding domain 2, pseudogene Neighboring gene STARR-positive B cell enhancer mm9_chr14:65644927-65645227 Neighboring gene predicted gene, 52118 Neighboring gene exostosin-like glycosyltransferase 3 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:65716318-65716519 Neighboring gene STARR-positive B cell enhancer ABC_E11573 Neighboring gene predicted gene, 52119 Neighboring gene STARR-positive B cell enhancer ABC_E388 Neighboring gene STARR-seq mESC enhancer starr_36964 Neighboring gene predicted gene, 30008 Neighboring gene predicted gene, 41177

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. USP24-dependent stabilization of Runx2 recruits a p300/NCOA3 complex to transactivate ADAMTS genes and promote degeneration of intervertebral disc in chronic inflammation mice. Li X, et al. Biol Direct, 2023 Jul 6. PMID 37415159, Free PMC Article
    2. Elf5-centered transcription factor hub controls trophoblast stem cell self-renewal and differentiation through stoichiometry-sensitive shifts in target gene networks. Latos PA, et al. Genes Dev, 2015 Dec 1. PMID 26584622, Free PMC Article
    3. Fgf and Esrrb integrate epigenetic and transcriptional networks that regulate self-renewal of trophoblast stem cells. Latos PA, et al. Nat Commun, 2015 Jul 24. PMID 26206133, Free PMC Article
    4. New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules. Das R, et al. J Cell Sci, 2019 Jun 17. PMID 31138677, Free PMC Article
    5. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of transforming growth factor beta receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in snRNA 3'-end processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in snRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in snRNA processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of integrator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of integrator complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of integrator complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    integrator complex subunit 9
    Names
    int9

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001253731.1 → NP_001240660.1  integrator complex subunit 9 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has an alternate splice site in the 5' region, which results in a downstream AUG start codon, compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AK077634, BQ033503, BY195822
      UniProtKB/TrEMBL
      A0A0R4J0J5
      Conserved Domains (2) summary
      smart01027
      Location:283 → 401
      Beta-Casp; Beta-Casp domain
      cl23716
      Location:60 → 241
      metallo-hydrolase-like_MBL-fold; mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain

    2. NM_153414.5 → NP_700463.3  integrator complex subunit 9 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AC141425, AC155172
      Consensus CDS
      CCDS27210.1
      UniProtKB/Swiss-Prot
      Q8BP62, Q8CAE4, Q8K114
      UniProtKB/TrEMBL
      A0A0R4J0J5
      Related
      ENSMUSP00000045552.7, ENSMUST00000043914.8
      Conserved Domains (2) summary
      smart01027
      Location:307 → 425
      Beta-Casp; Beta-Casp domain
      cd16294
      Location:1 → 265
      Int9-like_MBL-fold; integrator subunit 9, and related proteins; MBL-fold metallo-hydrolase domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      65187494..65277284
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8K114.1 GenPept UniProtKB/Swiss-Prot:Q8K114

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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