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    Tm4sf19 transmembrane 4 L six family member 19 [ Mus musculus (house mouse) ]

    Gene ID: 277203, updated on 21-Dec-2024

    Summary

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    Official Symbol
    Tm4sf19provided by MGI
    Official Full Name
    transmembrane 4 L six family member 19provided by MGI
    Primary source
    MGI:MGI:3645933
    See related
    Ensembl:ENSMUSG00000079625 AllianceGenome:MGI:3645933
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    EG277203
    Summary
    Predicted to be active in membrane. Is expressed in pancreas. Orthologous to human TM4SF19 (transmembrane 4 L six family member 19). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in testis adult (RPKM 1.2), spleen adult (RPKM 0.2) and 4 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tm4sf19 in Genome Data Viewer
    Location:
    16 B3; 16 22.66 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (32218823..32227397)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (32400012..32409234)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr16:32332099-32332400 Neighboring gene predicted gene 8387 Neighboring gene UBX domain protein 7 Neighboring gene predicted gene, 20056 Neighboring gene STARR-positive B cell enhancer ABC_E8997 Neighboring gene predicted gene, 53948 Neighboring gene dynein light chain Tctex-type 2B Neighboring gene STARR-positive B cell enhancer mm9_chr16:32430841-32431142 Neighboring gene STARR-positive B cell enhancer ABC_E9428 Neighboring gene phosphate cytidylyltransferase 1, choline, alpha isoform

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. TM4SF19-mediated control of lysosomal activity in macrophages contributes to obesity-induced inflammation and metabolic dysfunction. Choi C, et al. Nat Commun, 2024 Mar 30. PMID 38555350, Free PMC Article
    2. Tm4sf19 deficiency inhibits osteoclast multinucleation and prevents bone loss. Park S, et al. Metabolism, 2024 Feb. PMID 38016540
    3. Behavioral changes and growth deficits in a CRISPR engineered mouse model of the schizophrenia-associated 3q29 deletion. Rutkowski TP, et al. Mol Psychiatry, 2021 Mar. PMID 30976085, Free PMC Article
    4. The L6 domain tetraspanin Tm4sf4 regulates endocrine pancreas differentiation and directed cell migration. Anderson KR, et al. Development, 2011 Aug. PMID 21750032, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TM4SF19-mediated control of lysosomal activity in macrophages contributes to obesity-induced inflammation and metabolic dysfunction.
      Title: TM4SF19-mediated control of lysosomal activity in macrophages contributes to obesity-induced inflammation and metabolic dysfunction.
    2. Tm4sf19 deficiency inhibits osteoclast multinucleation and prevents bone loss.
      Title: Tm4sf19 deficiency inhibits osteoclast multinucleation and prevents bone loss.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane 4 L6 family member 19
    Names
    osteoclast maturation-associated gene 4 protein
    tetraspan membrane protein OCTM4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001160402.1 → NP_001153874.1  transmembrane 4 L6 family member 19

      See identical proteins and their annotated locations for NP_001153874.1

      Status: VALIDATED

      Source sequence(s)
      AC087556, BC147727
      Consensus CDS
      CCDS49827.1
      UniProtKB/Swiss-Prot
      B2RWD4, E9Q9H8
      Related
      ENSMUSP00000110802.3, ENSMUST00000115149.3
      Conserved Domains (1) summary
      pfam05805
      Location:10 → 204
      L6_membrane; L6 membrane protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      32218823..32227397
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006522217.3 → XP_006522280.1  transmembrane 4 L6 family member 19 isoform X1

      Conserved Domains (1) summary
      pfam05805
      Location:31 → 225
      L6_membrane; L6 membrane protein

    2. XM_006522221.4 → XP_006522284.1  transmembrane 4 L6 family member 19 isoform X2

      See identical proteins and their annotated locations for XP_006522284.1

      UniProtKB/Swiss-Prot
      B2RWD4, E9Q9H8
      Conserved Domains (1) summary
      pfam05805
      Location:10 → 204
      L6_membrane; L6 membrane protein

    3. XM_006522222.3 → XP_006522285.1  transmembrane 4 L6 family member 19 isoform X3

      Conserved Domains (1) summary
      pfam05805
      Location:31 → 100
      L6_membrane; L6 membrane protein
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    E9Q9H8.1 GenPept UniProtKB/Swiss-Prot:E9Q9H8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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