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    Rab31 RAB31, member RAS oncogene family [ Mus musculus (house mouse) ]

    Gene ID: 106572, updated on 24-Dec-2024

    Summary

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    Official Symbol
    Rab31provided by MGI
    Official Full Name
    RAB31, member RAS oncogene familyprovided by MGI
    Primary source
    MGI:MGI:1914603
    See related
    Ensembl:ENSMUSG00000056515 AllianceGenome:MGI:1914603
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Rab22B; 1700093E07Rik
    Summary
    Predicted to enable GDP binding activity; GTP binding activity; and GTPase activity. Involved in positive regulation of phagocytosis, engulfment. Located in early phagosome membrane and phagocytic cup. Is expressed in axial musculature; nervous system; submandibular gland primordium; and vibrissa. Orthologous to human RAB31 (RAB31, member RAS oncogene family). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in ovary adult (RPKM 24.0), cortex adult (RPKM 19.7) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Rab31 in Genome Data Viewer
    Location:
    17 E1.1; 17 35.03 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (65958721..66079747, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (65651726..65772752, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene vesicle-associated membrane protein, associated protein A Neighboring gene thioredoxin domain containing 2 (spermatozoa) Neighboring gene predicted gene, 35477 Neighboring gene STARR-seq mESC enhancer starr_43016 Neighboring gene STARR-seq mESC enhancer starr_43017 Neighboring gene STARR-seq mESC enhancer starr_43022 Neighboring gene STARR-seq mESC enhancer starr_43025 Neighboring gene protein phosphatase 4, regulatory subunit 1 Neighboring gene STARR-seq mESC enhancer starr_43027 Neighboring gene ralA binding protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E10964 Neighboring gene predicted gene, 49870

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Rab31 promotes activation of hepatic stellate cells by accelerating TGF-β receptor II complex endocytosis. Qiu C, et al. Int J Biochem Cell Biol, 2022 Mar. PMID 35091093
    2. Rab31 is expressed in neural progenitor cells and plays a role in their differentiation. Chua CE, et al. FEBS Lett, 2014 Aug 25. PMID 24999186
    3. Single-step protease cleavage elution for identification of protein-protein interactions from GST pull-down and mass spectrometry. Luo L, et al. Proteomics, 2014 Jan. PMID 24259493
    4. Engagement of the small GTPase Rab31 protein and its effector, early endosome antigen 1, is important for trafficking of the ligand-bound epidermal growth factor receptor from the early to the late endosome. Chua CE, et al. J Biol Chem, 2014 May 2. PMID 24644286, Free PMC Article
    5. Gapex-5, a Rab31 guanine nucleotide exchange factor that regulates Glut4 trafficking in adipocytes. Lodhi IJ, et al. Cell Metab, 2007 Jan. PMID 17189207, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Rab31 promotes activation of hepatic stellate cells by accelerating TGF-beta receptor II complex endocytosis.
      Title: Rab31 promotes activation of hepatic stellate cells by accelerating TGF-β receptor II complex endocytosis.
    2. Rab31, with APPL2 as its effector, play a role in FcgammaR-mediated phagocytosis through PI3K/Akt signaling in macrophages.
      Title: Rab31 and APPL2 enhance FcγR-mediated phagocytosis through PI3K/Akt signaling in macrophages.
    3. a previously unrecognised role for Rab31 in influencing the differentiation and fate of neural progenitor cells
      Title: Rab31 is expressed in neural progenitor cells and plays a role in their differentiation.
    4. Rab22B is exceptionally enriched in nestin and RC2-positive radial glia of the embryonic mouse brain. In the adult brain, Rab22B is rather specifically expressed in glial fibrillary acidic protein (GFAP)-positive mature astrocytes.
      Title: Rab22B is expressed in the CNS astroglia lineage and plays a role in epidermal growth factor receptor trafficking in A431 cells.
    5. Insulin recruits the CIP4/Gapex-5 complex to the plasma membrane, thus reducing Rab31 activity and permitting Glut4 vesicles to translocate to the cell surface, where Glut4 docks and fuses to transport glucose into the cell.
      Title: Gapex-5, a Rab31 guanine nucleotide exchange factor that regulates Glut4 trafficking in adipocytes.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GDP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables GDP binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables GTP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables GTP binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Golgi to plasma membrane protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in Golgi to plasma membrane protein transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in Golgi to plasma membrane protein transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in Golgi vesicle transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to insulin stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to insulin stimulus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phagosome maturation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phagosome maturation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of phagocytosis, engulfment IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in receptor internalization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in receptor internalization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulated exocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulated exocytosis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in early endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in early endosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in early phagosome membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in endomembrane system IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in late endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in late endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in phagocytic cup IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in phagocytic vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in phagocytic vesicle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in trans-Golgi network ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in trans-Golgi network membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in trans-Golgi network membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in trans-Golgi network membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    ras-related protein Rab-31

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_133685.2 → NP_598446.2  ras-related protein Rab-31

      See identical proteins and their annotated locations for NP_598446.2

      Status: VALIDATED

      Source sequence(s)
      AC139751, AC166058, AK051270, AK159095, BY761495
      Consensus CDS
      CCDS50166.1
      UniProtKB/Swiss-Prot
      Q8BKP0, Q921E2
      UniProtKB/TrEMBL
      Q3TXV4
      Related
      ENSMUSP00000068195.8, ENSMUST00000070673.9
      Conserved Domains (2) summary
      cd01860
      Location:6 → 168
      Rab5_related; Rab-related GTPase family includes Rab5 and Rab22; regulates early endosome fusion
      pfam00071
      Location:8 → 168
      Ras; Ras family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      65958721..66079747 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036160241.1 → XP_036016134.1  ras-related protein Rab-31 isoform X1

      Conserved Domains (1) summary
      cl38936
      Location:1 → 125
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q921E2.2 GenPept UniProtKB/Swiss-Prot:Q921E2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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