Mecom MDS1 and EVI1 complex locus [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mecomprovided by MGI
Official Full Name: MDS1 and EVI1 complex locusprovided by MGI
Primary source: MGI:MGI:95457
See related: Ensembl:ENSMUSG00000027684 AllianceGenome:MGI:95457
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Jbo; Mds; Evi1; Mds1; Evi-1; Prdm3; Znfpr1b1; Mds1-Evi1; D630039M04Rik
Summary: Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and histone H3K9 methyltransferase activity. Involved in hematopoietic stem cell proliferation; heterochromatin organization; and regulation of DNA-templated transcription. Acts upstream of or within several processes, including embryonic limb morphogenesis; positive regulation of brown fat cell differentiation; and ureter morphogenesis. Located in nucleus. Is expressed in several structures, including brain; embryo mesenchyme; genitourinary system; respiratory system; and sensory organ. Used to study otitis media. Human ortholog(s) of this gene implicated in myeloid neoplasm. Orthologous to human MECOM (MDS1 and EVI1 complex locus). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in bladder adult (RPKM 7.5), limb E14.5 (RPKM 5.2) and 15 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 A3; 3 12.66 cM

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (30005445..30563937, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (29951296..30509759, complement)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mecom mutation related to radioulnar synostosis with amegakaryocytic thrombocytopenia reduces HSPCs in mice.
Title: Mecom mutation related to radioulnar synostosis with amegakaryocytic thrombocytopenia reduces HSPCs in mice.
EVI1 exerts distinct roles in AML via ERG and cyclin D1 promoting a chemoresistant and immune-suppressive environment.
Title: EVI1 exerts distinct roles in AML via ERG and cyclin D1 promoting a chemoresistant and immune-suppressive environment.
Aberrant EVI1 splicing contributes to EVI1-rearranged leukemia.
Title: Aberrant EVI1 splicing contributes to EVI1-rearranged leukemia.
Evi1 upregulates Fbp1 and supports progression of acute myeloid leukemia through pentose phosphate pathway activation.
Title: Evi1 upregulates Fbp1 and supports progression of acute myeloid leukemia through pentose phosphate pathway activation.
EVI1 and GATA2 misexpression induced by inv(3)(q21q26) contribute to megakaryocyte-lineage skewing and leukemogenesis.
Title: EVI1 and GATA2 misexpression induced by inv(3)(q21q26) contribute to megakaryocyte-lineage skewing and leukemogenesis.
PRDM3 attenuates pancreatitis and pancreatic tumorigenesis by regulating inflammatory response.
Title: PRDM3 attenuates pancreatitis and pancreatic tumorigenesis by regulating inflammatory response.
Deletion of the Prdm3 Gene Causes a Neuronal Differentiation Deficiency in P19 Cells.
Title: Deletion of the Prdm3 Gene Causes a Neuronal Differentiation Deficiency in P19 Cells.
The conserved and divergent roles of Prdm3 and Prdm16 in zebrafish and mouse craniofacial development.
Title: The conserved and divergent roles of Prdm3 and Prdm16 in zebrafish and mouse craniofacial development.
Prdm3 and Prdm16 cooperatively maintain hematopoiesis and clonogenic potential.
Title: Prdm3 and Prdm16 cooperatively maintain hematopoiesis and clonogenic potential.
All-trans retinoic acid enhances, and a pan-RAR antagonist counteracts, the stem cell promoting activity of EVI1 in acute myeloid leukemia.
Title: All-trans retinoic acid enhances, and a pan-RAR antagonist counteracts, the stem cell promoting activity of EVI1 in acute myeloid leukemia.

Submit: New GeneRIF Correction See all GeneRIFs (46)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (1) 1 citation
Endonuclease-mediated (5) 1 citation
Targeted (12) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Evi1 (e-PCR), detects polymorphism
- UniSTS:506889

D3Mit46 (e-PCR), detects polymorphism
- UniSTS:129814

D3Mit46.1 (e-PCR), detects polymorphism
- UniSTS:129815

D3Mit178 (e-PCR), detects polymorphism
- UniSTS:129595

UniSTS:142399 (e-PCR)
- UniSTS:142399

D3Mit46.3 (e-PCR), detects polymorphism
- UniSTS:142399

AU019034 (e-PCR)
- UniSTS:159101

AI503489 (e-PCR)
- UniSTS:178818

NoName (e-PCR)
- UniSTS:234651

D3Mit271 (e-PCR), detects polymorphism
- UniSTS:129699

Evi1 (e-PCR), detects polymorphism
- UniSTS:256973

Evi1 (e-PCR), detects polymorphism
- UniSTS:256974

AJ010015 (e-PCR)
- UniSTS:163309

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IC Inferred by Curator more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IMP Inferred from Mutant Phenotype more info	PubMed
enables DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables histone H3K9 methyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables histone H3K9 monomethyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H3K9me2 methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within embryonic forelimb morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within embryonic hindlimb morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within forebrain development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hematopoietic stem cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heterochromatin organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within in utero embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within maintenance of cell number	IGI Inferred from Genetic Interaction more info	PubMed
involved_in methylation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of JNK cascade	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of JNK cascade	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of programmed cell death	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of programmed cell death	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within neutrophil homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within pericardium development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of brown fat cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within post-embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell cycle	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell cycle	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of hematopoietic stem cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within response to bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within ureter morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
part_of histone deacetylase complex	ISO Inferred from Sequence Orthology more info
part_of histone deacetylase complex	ISS Inferred from Sequence or Structural Similarity more info
located_in nuclear speck	ISO Inferred from Sequence Orthology more info
located_in nuclear speck	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: histone-lysine N-methyltransferase MECOM

Names: MDS1 and EVI1 complex locus protein EVI1; MDS1 and EVI1 complex locus protein MDS1; ecotropic viral integration site 1; ecotropic virus integration site 1 protein; myelodysplasia syndrome 1 protein homolog

NP_001347963.1

EC 2.1.1.367

NP_001357697.1

EC 2.1.1.367

NP_001357698.1

EC 2.1.1.367

NP_031989.2

EC 2.1.1.367

NP_067417.1

EC 2.1.1.367

XP_006535456.1

EC 2.1.1.367

XP_006535457.1

EC 2.1.1.367

XP_011247958.1

EC 2.1.1.367

XP_011247961.1

EC 2.1.1.367

XP_011247962.1

EC 2.1.1.367

XP_011247963.1

EC 2.1.1.367

XP_011247964.1

EC 2.1.1.367

XP_011247965.1

EC 2.1.1.367

XP_011247966.1

EC 2.1.1.367

XP_017174943.1

EC 2.1.1.367

XP_030108276.1

EC 2.1.1.367

XP_036018781.1

EC 2.1.1.367

XP_036018782.1

EC 2.1.1.367

XP_036018783.1

EC 2.1.1.367

XP_036018784.1

EC 2.1.1.367

XP_036018785.1

EC 2.1.1.367

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001361034.4 → NP_001347963.1 histone-lysine N-methyltransferase MECOM isoform 3

Status: VALIDATED

Source sequence(s)

AC119995, AL691419, AL772145, AL929377

Conserved Domains (6) summary

PHA00733
Location:880 → 976

PHA00733; hypothetical protein

smart00317
Location:90 → 194

SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain

sd00017
Location:926 → 946

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:924 → 946

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:938 → 962

zf-H2C2_2; Zinc-finger double domain

pfam15909
Location:354 → 438

zf-C2H2_8; C2H2-type zinc ribbon
NM_001370768.3 → NP_001357697.1 histone-lysine N-methyltransferase MECOM isoform 4

Status: VALIDATED

Source sequence(s)

AC119995, AL691419, AL772145, AL929377

Conserved Domains (6) summary

PHA00733
Location:848 → 967

PHA00733; hypothetical protein

smart00317
Location:90 → 194

SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain

sd00017
Location:917 → 937

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam15909
Location:354 → 438

zf-C2H2_8; C2H2-type zinc ribbon

pfam00096
Location:915 → 937

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:929 → 953

zf-H2C2_2; Zinc-finger double domain
NM_001370769.3 → NP_001357698.1 histone-lysine N-methyltransferase MECOM isoform 5

Status: VALIDATED

Source sequence(s)

AC119995, AL691419, AL772145, AL929377

UniProtKB/Swiss-Prot

G3UWT0, P14404, Q9Z1L8

Conserved Domains (6) summary

PHA00733
Location:847 → 966

PHA00733; hypothetical protein

smart00317
Location:90 → 194

SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain

sd00017
Location:916 → 936

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam15909
Location:353 → 437

zf-C2H2_8; C2H2-type zinc ribbon

pfam00096
Location:914 → 936

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:928 → 952

zf-H2C2_2; Zinc-finger double domain
NM_001428445.1 → NP_001415374.1 histone-lysine N-methyltransferase MECOM isoform 6

Status: VALIDATED

Source sequence(s)

AL772145, AL929377
NM_001428446.1 → NP_001415375.1 histone-lysine N-methyltransferase MECOM isoform 7

Status: VALIDATED

Source sequence(s)

AL772145, AL929377

UniProtKB/TrEMBL

H9T841
NM_001428447.1 → NP_001415376.1 histone-lysine N-methyltransferase MECOM isoform 8

Status: VALIDATED

Source sequence(s)

AL772145, AL929377

UniProtKB/TrEMBL

G3UZT5
NM_001428448.1 → NP_001415377.1 histone-lysine N-methyltransferase MECOM isoform 9

Status: VALIDATED

Source sequence(s)

AL772145, AL929377
NM_001428449.1 → NP_001415378.1 histone-lysine N-methyltransferase MECOM isoform 10

Status: VALIDATED

Source sequence(s)

AL772145, AL929377
NM_001428450.1 → NP_001415379.1 histone-lysine N-methyltransferase MECOM isoform 11

Status: VALIDATED

Source sequence(s)

AC119995, AL691419, AL772145, AL929377
NM_007963.3 → NP_031989.2 histone-lysine N-methyltransferase MECOM isoform 1

Status: VALIDATED

Source sequence(s)

AL772145, AL929377

Consensus CDS

CCDS17281.2

UniProtKB/TrEMBL

G3UZ13, Q8CCA6

Related

ENSMUSP00000134303.2, ENSMUST00000172694.8

Conserved Domains (4) summary

PHA00733
Location:333 → 452

PHA00733; hypothetical protein

sd00017
Location:402 → 422

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:400 → 422

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:414 → 438

zf-H2C2_2; Zinc-finger double domain
NM_021442.3 → NP_067417.1 histone-lysine N-methyltransferase MECOM isoform 2

See identical proteins and their annotated locations for NP_067417.1

Status: VALIDATED

Source sequence(s)

AC119995, AL691419

UniProtKB/TrEMBL

F6SZX1

Related

ENSMUST00000173022.2

Conserved Domains (1) summary

cl02566
Location:90 → 118

SET; SET domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000069.7 Reference GRCm39 C57BL/6J

Range

30005445..30563937 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036162888.1 → XP_036018781.1 histone-lysine N-methyltransferase MECOM isoform X4

Related

ENSMUSP00000133410.2, ENSMUST00000173899.8

Conserved Domains (6) summary

PHA00733
Location:847 → 966

PHA00733; hypothetical protein

COG5189
Location:304 → 397

SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]

sd00017
Location:916 → 936

ZF_C2H2; C2H2 Zn finger [structural motif]

cl40432
Location:49 → 206

SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily

pfam00096
Location:914 → 936

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:928 → 952

zf-H2C2_2; Zinc-finger double domain
XM_011249664.4 → XP_011247966.1 histone-lysine N-methyltransferase MECOM isoform X15

UniProtKB/TrEMBL

G3UWJ0

Conserved Domains (3) summary

COG5048
Location:300 → 757

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:601 → 621

ZF_C2H2; C2H2 Zn finger [structural motif]

cl40432
Location:58 → 215

SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily
XM_011249663.1 → XP_011247965.1 histone-lysine N-methyltransferase MECOM isoform X13

UniProtKB/TrEMBL

G3UWJ0

Related

ENSMUSP00000133310.2, ENSMUST00000173059.8

Conserved Domains (3) summary

COG5048
Location:263 → 720

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:564 → 584

ZF_C2H2; C2H2 Zn finger [structural motif]

cl40432
Location:21 → 178

SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily
XM_011249660.3 → XP_011247962.1 histone-lysine N-methyltransferase MECOM isoform X3

UniProtKB/TrEMBL

O35700

Conserved Domains (5) summary

PHA00733
Location:851 → 947

PHA00733; hypothetical protein

sd00017
Location:897 → 917

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:895 → 917

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:909 → 933

zf-H2C2_2; Zinc-finger double domain

cl40432
Location:21 → 178

SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily
XM_011249656.1 → XP_011247958.1 histone-lysine N-methyltransferase MECOM isoform X1

Conserved Domains (5) summary

PHA00733
Location:851 → 947

PHA00733; hypothetical protein

sd00017
Location:897 → 917

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:895 → 917

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:909 → 933

zf-H2C2_2; Zinc-finger double domain

cl40432
Location:21 → 178

SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily
XM_011249662.1 → XP_011247964.1 histone-lysine N-methyltransferase MECOM isoform X12

UniProtKB/TrEMBL

G3UWJ0

Conserved Domains (6) summary

PHA00733
Location:528 → 624

PHA00733; hypothetical protein

COG5048
Location:263 → 615

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:574 → 594

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:572 → 594

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:586 → 610

zf-H2C2_2; Zinc-finger double domain

cl40432
Location:21 → 178

SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily
XM_011249659.3 → XP_011247961.1 histone-lysine N-methyltransferase MECOM isoform X2

UniProtKB/TrEMBL

O35700

Conserved Domains (5) summary

PHA00733
Location:852 → 948

PHA00733; hypothetical protein

sd00017
Location:898 → 918

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:896 → 918

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:910 → 934

zf-H2C2_2; Zinc-finger double domain

cl40432
Location:21 → 178

SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily
XM_011249661.4 → XP_011247963.1 histone-lysine N-methyltransferase MECOM isoform X7

See identical proteins and their annotated locations for XP_011247963.1

UniProtKB/TrEMBL

O35700

Conserved Domains (4) summary

PHA00733
Location:690 → 786

PHA00733; hypothetical protein

sd00017
Location:736 → 756

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:734 → 756

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:748 → 772

zf-H2C2_2; Zinc-finger double domain
XM_036162891.1 → XP_036018784.1 histone-lysine N-methyltransferase MECOM isoform X10

Related

ENSMUSP00000103905.4, ENSMUST00000108270.10

Conserved Domains (5) summary

PHA00733
Location:657 → 776

PHA00733; hypothetical protein

sd00017
Location:726 → 746

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:724 → 746

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:738 → 762

zf-H2C2_2; Zinc-finger double domain

cd20908
Location:136 → 178

SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins
XM_036162892.1 → XP_036018785.1 histone-lysine N-methyltransferase MECOM isoform X11

Related

ENSMUSP00000128563.2, ENSMUST00000166001.8

Conserved Domains (5) summary

PHA00733
Location:657 → 776

PHA00733; hypothetical protein

COG5189
Location:114 → 207

SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]

sd00017
Location:726 → 746

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:188 → 210

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:738 → 762

zf-H2C2_2; Zinc-finger double domain
XM_030252416.2 → XP_030108276.1 histone-lysine N-methyltransferase MECOM isoform X8

Related

ENSMUSP00000134626.2, ENSMUST00000173495.8

Conserved Domains (4) summary

PHA00733
Location:689 → 785

PHA00733; hypothetical protein

sd00017
Location:735 → 755

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:733 → 755

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:747 → 771

zf-H2C2_2; Zinc-finger double domain
XM_036162890.1 → XP_036018783.1 histone-lysine N-methyltransferase MECOM isoform X9

Conserved Domains (4) summary

PHA00733
Location:658 → 777

PHA00733; hypothetical protein

sd00017
Location:727 → 747

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:725 → 747

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:739 → 763

zf-H2C2_2; Zinc-finger double domain
XM_006535394.4 → XP_006535457.1 histone-lysine N-methyltransferase MECOM isoform X7

Conserved Domains (4) summary

PHA00733
Location:690 → 786

PHA00733; hypothetical protein

sd00017
Location:736 → 756

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:734 → 756

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:748 → 772

zf-H2C2_2; Zinc-finger double domain
XM_036162889.1 → XP_036018782.1 histone-lysine N-methyltransferase MECOM isoform X6

UniProtKB/TrEMBL

O35700

Conserved Domains (6) summary

PHA00733
Location:753 → 849

PHA00733; hypothetical protein

COG5189
Location:178 → 271

SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]

sd00017
Location:799 → 819

ZF_C2H2; C2H2 Zn finger [structural motif]

cl40432
Location:2 → 80

SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily

pfam00096
Location:797 → 819

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:811 → 835

zf-H2C2_2; Zinc-finger double domain
XM_006535393.5 → XP_006535456.1 histone-lysine N-methyltransferase MECOM isoform X5

UniProtKB/TrEMBL

O35700

Conserved Domains (6) summary

PHA00733
Location:754 → 850

PHA00733; hypothetical protein

sd00017
Location:800 → 820

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:798 → 820

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:812 → 836

zf-H2C2_2; Zinc-finger double domain

pfam15909
Location:228 → 312

zf-C2H2_8; C2H2-type zinc ribbon

cl40432
Location:2 → 80

SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily
XM_017319454.3 → XP_017174943.1 histone-lysine N-methyltransferase MECOM isoform X14

UniProtKB/TrEMBL

G3UYK2

Conserved Domains (4) summary

sd00017
Location:304 → 324

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:388 → 410

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:288 → 312

zf-H2C2_2; Zinc-finger double domain

cl40432
Location:58 → 215

SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily