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    Cnpy4 canopy FGF signaling regulator 4 [ Mus musculus (house mouse) ]

    Gene ID: 66455, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cnpy4provided by MGI
    Official Full Name
    canopy FGF signaling regulator 4provided by MGI
    Primary source
    MGI:MGI:1913705
    See related
    Ensembl:ENSMUSG00000036968 AllianceGenome:MGI:1913705
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2610019P18Rik
    Summary
    Enables signaling receptor binding activity. Predicted to be involved in positive regulation of protein localization to plasma membrane. Predicted to act upstream of or within regulation of protein localization. Predicted to be located in extracellular region. Is expressed in arm and hindlimb. Orthologous to human CNPY4 (canopy FGF signaling regulator 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in CNS E11.5 (RPKM 23.1), limb E14.5 (RPKM 12.8) and 19 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cnpy4 in Genome Data Viewer
    Location:
    5 G2; 5 76.98 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (138185768..138192180)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (138187535..138193894)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene microRNA 106b Neighboring gene minichromosome maintenance complex component 7 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:138612151-138612338 Neighboring gene STARR-positive B cell enhancer ABC_E1693 Neighboring gene STARR-positive B cell enhancer ABC_E1694 Neighboring gene adaptor-related protein complex AP-4, mu 1 Neighboring gene TATA-box binding protein associated factor 6 Neighboring gene STARR-seq mESC enhancer starr_14665 Neighboring gene metallo-beta-lactamase domain containing 1 Neighboring gene predicted gene 454

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. CNPY4 inhibits the Hedgehog pathway by modulating membrane sterol lipids. Lo M, et al. Nat Commun, 2022 May 3. PMID 35504891, Free PMC Article
    2. A molecule that is associated with Toll-like receptor 4 and regulates its cell surface expression. Konno K, et al. Biochem Biophys Res Commun, 2006 Jan 27. PMID 16338228
    3. Histone H3.3 maintains genome integrity during mammalian development. Jang CW, et al. Genes Dev, 2015 Jul 1. PMID 26159997, Free PMC Article
    4. A mouse knockout library for secreted and transmembrane proteins. Tang T, et al. Nat Biotechnol, 2010 Jul. PMID 20562862
    5. Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors. Kim H, et al. Cell, 2018 Dec 13. PMID 30550785, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (3)  1 citation
    • Transgenic (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables signaling receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables signaling receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of protein localization to plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of protein localization to plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of protein localization ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein canopy homolog 4
    Names
    canopy 4 homolog
    protein associated with Tlr4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001419173.1 → NP_001406102.1  protein canopy homolog 4 isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      AC151719, AC159257

    2. NM_001419174.1 → NP_001406103.1  protein canopy homolog 4 isoform 3 precursor

      Status: VALIDATED

      Source sequence(s)
      AC151719, AC159257

    3. NM_178612.5 → NP_848727.1  protein canopy homolog 4 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC151719, AC159257
      Consensus CDS
      CCDS39341.1
      UniProtKB/Swiss-Prot
      Q8BQ47, Q8BT84, Q8BTB1, Q8CCG0
      Related
      ENSMUSP00000106559.3, ENSMUST00000110934.9
      Conserved Domains (1) summary
      pfam11938
      Location:43 → 191
      DUF3456; TLR4 regulator and MIR-interacting MSAP

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      138185768..138192180
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BQ47.1 GenPept UniProtKB/Swiss-Prot:Q8BQ47

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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