Zar1 zygote arrest 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Zar1provided by MGI
Official Full Name: zygote arrest 1provided by MGI
Primary source: MGI:MGI:2180337
See related: Ensembl:ENSMUSG00000063935 AllianceGenome:MGI:2180337
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Enables RNA sequestering activity; mRNA 3'-UTR binding activity; and molecular condensate scaffold activity. Involved in membraneless organelle assembly; oocyte maturation; and post-transcriptional regulation of gene expression. Is active in cytoplasm and intracellular membraneless organelle. Is expressed in early conceptus; ovary; and rib. Orthologous to human ZAR1 (zygote arrest 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward ovary adult (RPKM 33.1) See more
Orthologs: human all
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Genomic context

Location:: 5 C3.2; 5 38.44 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (72734457..72738427, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (72577113..72581361, complement)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Genome transfer for the prevention of female infertility caused by maternal gene mutation.
Title: Genome transfer for the prevention of female infertility caused by maternal gene mutation.
A previously unrecognized role of ZAR1/2 in regulating the maternal transcriptome and translational activation in maturing oocytes.
Title: ZAR1 and ZAR2 are required for oocyte meiotic maturation by regulating the maternal transcriptome and mRNA translational activation.
The highest Zar1 mRNA levels were detected in oocytes in the pre-antral follicle stage.
Title: Quantification of oocyte-specific transcripts in follicle-enclosed oocytes during antral development and maturation in vitro.
Promoter activities of three mouse maternal genes (H1oo, Npm2, and Zar1) in oocytes and pre-implantation embryos, and examined the promoters and to obttain the best promoter for oocytte gene expression.
Title: Cis-acting elements (E-box and NBE) in the promoter region of three maternal genes (Histone H1oo, Nucleoplasmin 2, and Zygote Arrest 1) are required for oocyte-specific gene expression in the mouse.
The carboxyl-termini of these ZAR1 proteins contain an important functional domain that is conserved through vertebrate evolution and that may be necessary for normal female reproduction in the transition from oocyte to embryonic life.
Title: Zygote arrest 1 (Zar1) is an evolutionarily conserved gene expressed in vertebrate ovaries.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3) 1 citation
Targeted (1) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA sequestering activity	IDA Inferred from Direct Assay more info	PubMed
enables mRNA 3'-UTR binding	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables molecular condensate scaffold activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in mRNA stabilization	IDA Inferred from Direct Assay more info	PubMed
involved_in membraneless organelle assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of translation	IDA Inferred from Direct Assay more info	PubMed
involved_in oocyte maturation	IDA Inferred from Direct Assay more info	PubMed
involved_in translation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasmic ribonucleoprotein granule	IEA Inferred from Electronic Annotation more info
is_active_in intracellular membraneless organelle	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: zygote arrest protein 1

Names: oocyte-specific maternal effect factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.