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    Htatip2 HIV-1 Tat interactive protein 2 [ Mus musculus (house mouse) ]

    Gene ID: 53415, updated on 9-Dec-2024

    Summary

    Official Symbol
    Htatip2provided by MGI
    Official Full Name
    HIV-1 Tat interactive protein 2provided by MGI
    Primary source
    MGI:MGI:1859271
    See related
    Ensembl:ENSMUSG00000039745 AllianceGenome:MGI:1859271
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cc3; Tip30
    Summary
    Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in import into nucleus and regulation of angiogenesis. Predicted to act upstream of or within positive regulation of programmed cell death; positive regulation of transcription by RNA polymerase II; and protein autophosphorylation. Predicted to be located in cytosol and nuclear envelope. Predicted to be active in cytoplasm. Is expressed in heart and limb. Orthologous to human HTATIP2 (HIV-1 Tat interactive protein 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in bladder adult (RPKM 15.4), placenta adult (RPKM 12.5) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Htatip2 in Genome Data Viewer
    Location:
    7 B4; 7 31.44 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (49408761..49423748)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (49759045..49774000)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 45985 Neighboring gene STARR-seq mESC enhancer starr_18912 Neighboring gene predicted gene, 32962 Neighboring gene STARR-positive B cell enhancer ABC_E11738 Neighboring gene predicted gene, 45986 Neighboring gene protein arginine N-methyltransferase 3 Neighboring gene STARR-seq mESC enhancer starr_18916 Neighboring gene STARR-seq mESC enhancer starr_18918 Neighboring gene solute carrier family 6 (neurotransmitter transporter, glycine), member 5

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables NAD binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in angiogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in import into nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in import into nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in import into nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of programmed cell death ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of angiogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear envelope ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear envelope ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 

    General protein information

    Preferred Names
    oxidoreductase HTATIP2
    Names
    HIV-1 tat interactive protein 2, 30 kDa homolog
    HIV-1 tat interactive protein 2, homolog
    tat-interacting protein 30 kDa
    NP_001139521.1
    NP_001139522.1
    NP_001139524.1
    NP_001139525.1
    NP_058561.2
    XP_006541052.1
    XP_030098630.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001146049.1NP_001139521.1  oxidoreductase HTATIP2 isoform b

      See identical proteins and their annotated locations for NP_001139521.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and uses a downstream translational start codon, compared to variant 1. The resulting isoform (b) is shorter at the N-terminus, compared to isoform a. Variants 2-5 encode the same isoform.
      Source sequence(s)
      AK144837, AW121187, BY292123
      Consensus CDS
      CCDS52260.1
      UniProtKB/Swiss-Prot
      Q810Y5, Q99KN6, Q9D5F8, Q9D804, Q9Z2G9
      Related
      ENSMUSP00000082374.6, ENSMUST00000085272.7
      Conserved Domains (1) summary
      cd05250
      Location:19231
      CC3_like_SDR_a; CC3(TIP30)-like, atypical (a) SDRs
    2. NM_001146050.1NP_001139522.1  oxidoreductase HTATIP2 isoform b

      See identical proteins and their annotated locations for NP_001139522.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream translational start codon, compared to variant 1. The resulting isoform (b) is shorter at the N-terminus, compared to isoform a. Variants 2-5 encode the same isoform.
      Source sequence(s)
      AK151254, AW121187, BB575839, CB593552
      Consensus CDS
      CCDS52260.1
      UniProtKB/Swiss-Prot
      Q810Y5, Q99KN6, Q9D5F8, Q9D804, Q9Z2G9
      Conserved Domains (1) summary
      cd05250
      Location:19231
      CC3_like_SDR_a; CC3(TIP30)-like, atypical (a) SDRs
    3. NM_001146052.1NP_001139524.1  oxidoreductase HTATIP2 isoform b

      See identical proteins and their annotated locations for NP_001139524.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream translational start codon, compared to variant 1. The resulting isoform (b) is shorter at the N-terminus, compared to isoform a. Variants 2-5 encode the same isoform.
      Source sequence(s)
      AK008630, AK151254, AW121187, CB318388
      Consensus CDS
      CCDS52260.1
      UniProtKB/Swiss-Prot
      Q810Y5, Q99KN6, Q9D5F8, Q9D804, Q9Z2G9
      Conserved Domains (1) summary
      cd05250
      Location:19231
      CC3_like_SDR_a; CC3(TIP30)-like, atypical (a) SDRs
    4. NM_001146053.1NP_001139525.1  oxidoreductase HTATIP2 isoform b

      See identical proteins and their annotated locations for NP_001139525.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream translational start codon, compared to variant 1. The resulting isoform (b) is shorter at the N-terminus, compared to isoform a. Variants 2-5 encode the same isoform.
      Source sequence(s)
      AK151254, AW121187, BB575839
      Consensus CDS
      CCDS52260.1
      UniProtKB/Swiss-Prot
      Q810Y5, Q99KN6, Q9D5F8, Q9D804, Q9Z2G9
      Conserved Domains (1) summary
      cd05250
      Location:19231
      CC3_like_SDR_a; CC3(TIP30)-like, atypical (a) SDRs
    5. NM_016865.3NP_058561.2  oxidoreductase HTATIP2 isoform a

      See identical proteins and their annotated locations for NP_058561.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (a).
      Source sequence(s)
      AK151254, AW121187, BY292123
      Consensus CDS
      CCDS85310.1
      UniProtKB/TrEMBL
      Q3U816
      Related
      ENSMUSP00000146858.2, ENSMUST00000207895.2
      Conserved Domains (2) summary
      cd05250
      Location:52264
      CC3_like_SDR_a; CC3(TIP30)-like, atypical (a) SDRs
      COG0702
      Location:54226
      YbjT; Uncharacterized conserved protein YbjT, contains NAD(P)-binding and DUF2867 domains [General function prediction only]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      49408761..49423748
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030242770.2XP_030098630.1  oxidoreductase HTATIP2 isoform X2

      Conserved Domains (1) summary
      cd05250
      Location:19219
      CC3_like_SDR_a; CC3(TIP30)-like, atypical (a) SDRs
    2. XM_006540989.1XP_006541052.1  oxidoreductase HTATIP2 isoform X1

      Conserved Domains (1) summary
      cd05250
      Location:52252
      CC3_like_SDR_a; CC3(TIP30)-like, atypical (a) SDRs