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    RIX7 putative AAA family ATPase RIX7 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850625, updated on 9-Dec-2024

    Summary

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    Official Symbol
    RIX7
    Official Full Name
    putative AAA family ATPase RIX7
    Primary source
    SGD:S000003957
    Locus tag
    YLL034C
    See related
    AllianceGenome:SGD:S000003957; FungiDB:YLL034C; VEuPathDB:YLL034C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable ATP hydrolysis activity and preribosome binding activity. Involved in ribosomal large subunit biogenesis and ribosomal large subunit export from nucleus. Located in nucleolus. Part of preribosome, large subunit precursor. Orthologous to human NVL (nuclear VCP like). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See RIX7 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (70633..73146, complement)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene E3 ubiquitin-protein ligase PRP19 Neighboring gene polynucleotide 5'-hydroxyl-kinase Neighboring gene Irc19p Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A nuclear AAA-type ATPase (Rix7p) is required for biogenesis and nuclear export of 60S ribosomal subunits. Gadal O, et al. EMBO J, 2001 Jul 16. PMID 11447111, Free PMC Article
    2. Functional analysis of six novel ORFs on the left arm of chromosome XII in Saccharomyces cerevisiae reveals two essential genes, one of which is under cell-cycle control. El-Moghazy AN, et al. Yeast, 2000 Feb. PMID 10649456
    3. Formation and nuclear export of preribosomes are functionally linked to the small-ubiquitin-related modifier pathway. Panse VG, et al. Traffic, 2006 Oct. PMID 16978391, Free PMC Article
    4. Mak5 and Ebp2 act together on early pre-60S particles and their reduced functionality bypasses the requirement for the essential pre-60S factor Nsa1. Pratte D, et al. PLoS One, 2013. PMID 24312670, Free PMC Article
    5. Visualizing the Assembly Pathway of Nucleolar Pre-60S Ribosomes. Kater L, et al. Cell, 2017 Dec 14. PMID 29245012, Free PMC Article

    See all (61) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Rix7 is required for the release of Nsa1 from a discrete preribosomal particle, thereby triggering the progression of 60S ribosome biogenesis.
      Title: The AAA ATPase Rix7 powers progression of ribosome biogenesis by stripping Nsa1 from pre-60S particles.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables preribosome binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in ribosomal large subunit biogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in ribosomal large subunit biogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ribosomal large subunit export from nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ribosome biogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ribosome biogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleolus HDA PubMed 
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of preribosome, large subunit precursor IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    putative AAA family ATPase RIX7
    NP_013066.1
    • Putative ATPase of the AAA family; required for export of pre-ribosomal large subunits from the nucleus; distributed between the nucleolus, nucleoplasm, and nuclear periphery depending on growth conditions

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      70633..73146 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181854.1 → NP_013066.1  TPA: putative AAA family ATPase RIX7 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013066.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VXX1, Q07844
      UniProtKB/TrEMBL
      B3LTD8, C8ZCT9, N1P6V6
      Conserved Domains (1) summary
      TIGR01243
      Location:192 → 824
      CDC48; AAA family ATPase, CDC48 subfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q07844.1

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