U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Cd109 CD109 antigen [ Mus musculus (house mouse) ]

    Gene ID: 235505, updated on 9-Dec-2024

    Summary

    Official Symbol
    Cd109provided by MGI
    Official Full Name
    CD109 antigenprovided by MGI
    Primary source
    MGI:MGI:2445221
    See related
    Ensembl:ENSMUSG00000046186 AllianceGenome:MGI:2445221
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    GARP; 9930012E15Rik
    Summary
    Predicted to enable transforming growth factor beta binding activity. Acts upstream of or within several processes, including negative regulation of cell population proliferation; osteoclast fusion; and regulation of keratinocyte differentiation. Located in extracellular space. Is expressed in brain; notochord; and nucleus pulposus. Orthologous to human CD109 (CD109 molecule). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in limb E14.5 (RPKM 3.2), testis adult (RPKM 3.0) and 15 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Cd109 in Genome Data Viewer
    Location:
    9 E1; 9 43.65 cM
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (78522828..78623542)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (78615546..78716260)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_24732 Neighboring gene STARR-seq mESC enhancer starr_24733 Neighboring gene predicted gene, 53210 Neighboring gene STARR-seq mESC enhancer starr_24735 Neighboring gene STARR-seq mESC enhancer starr_24737 Neighboring gene solute carrier family 17 (anion/sugar transporter), member 5 Neighboring gene STARR-positive B cell enhancer ABC_E3847 Neighboring gene STARR-positive B cell enhancer mm9_chr9:78444699-78445000 Neighboring gene STARR-seq mESC enhancer starr_24739 Neighboring gene STARR-positive B cell enhancer mm9_chr9:78548450-78548751 Neighboring gene STARR-seq mESC enhancer starr_24741 Neighboring gene STARR-seq mESC enhancer starr_24742 Neighboring gene predicted gene, 46138 Neighboring gene predicted gene, 39376

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Gene trapped (1) 
    • Targeted (3)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables serine-type endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables transforming growth factor beta binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within hair follicle development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of keratinocyte proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of keratinocyte proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of stem cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of transforming growth factor beta receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of transforming growth factor beta receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of wound healing IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of wound healing ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within osteoclast fusion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of keratinocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of stem cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular space HDA PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in side of membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    CD109 antigen
    Names
    GPI-anchored alpha 2 macroglobulin-related protein
    Gov platelet alloantigens

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_153098.3NP_694738.1  CD109 antigen precursor

      See identical proteins and their annotated locations for NP_694738.1

      Status: VALIDATED

      Source sequence(s)
      AI850351, DQ832284
      Consensus CDS
      CCDS23365.1
      UniProtKB/Swiss-Prot
      Q8BLT6, Q8R422
      UniProtKB/TrEMBL
      A6MDD3
      Related
      ENSMUSP00000091330.5, ENSMUST00000093812.5
      Conserved Domains (7) summary
      COG2373
      Location:1221002
      YfaS; Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function prediction only]
      cd02897
      Location:9091195
      A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...
      pfam00207
      Location:695782
      A2M; Alpha-2-macroglobulin family
      pfam01835
      Location:129220
      A2M_N; MG2 domain
      pfam07677
      Location:13111395
      A2M_recep; A-macroglobulin receptor
      pfam07678
      Location:9611197
      A2M_comp; A-macroglobulin complement component
      pfam07703
      Location:475598
      A2M_N_2; Alpha-2-macroglobulin family N-terminal region

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      78522828..78623542
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)