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    Itgb8 integrin beta 8 [ Mus musculus (house mouse) ]

    Gene ID: 320910, updated on 9-Dec-2024

    Summary

    Official Symbol
    Itgb8provided by MGI
    Official Full Name
    integrin beta 8provided by MGI
    Primary source
    MGI:MGI:1338035
    See related
    Ensembl:ENSMUSG00000025321 AllianceGenome:MGI:1338035
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4832412O06Rik
    Summary
    Predicted to enable extracellular matrix protein binding activity and integrin binding activity. Acts upstream of or within several processes, including Langerhans cell differentiation; hard palate development; and transforming growth factor beta receptor signaling pathway. Part of integrin alphav-beta8 complex. Is expressed in several structures, including alimentary system; male reproductive system; nervous system; sensory organ; and skeleton. Orthologous to human ITGB8 (integrin subunit beta 8). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in kidney adult (RPKM 9.7), CNS E11.5 (RPKM 3.6) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Itgb8 in Genome Data Viewer
    Location:
    12 F2; 12 63.48 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (119121757..119202891, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (119162803..119238276, complement)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene ATP-binding cassette, sub-family B member 5 Neighboring gene STARR-seq mESC enhancer starr_33448 Neighboring gene STARR-positive B cell enhancer mm9_chr12:120165112-120165412 Neighboring gene STARR-seq mESC enhancer starr_33449 Neighboring gene STARR-seq mESC enhancer starr_33450 Neighboring gene STARR-seq mESC enhancer starr_33451 Neighboring gene STARR-seq mESC enhancer starr_33453 Neighboring gene acyl-Coenzyme A binding domain containing 5 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E11529 Neighboring gene STARR-seq mESC enhancer starr_33455 Neighboring gene STARR-positive B cell enhancer mm9_chr12:120395620-120395921 Neighboring gene predicted gene, 52023 Neighboring gene nuclear receptor coactivator 4, pseudogene Neighboring gene predicted gene, 39562

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (5)  1 citation

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables extracellular matrix protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables extracellular matrix protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables integrin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables signaling receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables signaling receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within Langerhans cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in cartilage development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cartilage development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell adhesion mediated by integrin IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell-cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell-matrix adhesion NAS
    Non-traceable Author Statement
    more info
    PubMed 
    acts_upstream_of_or_within ganglioside metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within hard palate development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within immune response IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in integrin-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in integrin-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of angiogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within response to virus IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within transforming growth factor beta receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in vasculogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in vasculogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    is_active_in cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cell surface IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in focal adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of integrin alphav-beta8 complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of integrin alphav-beta8 complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of integrin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_177290.4NP_796264.2  integrin beta-8 precursor

      See identical proteins and their annotated locations for NP_796264.2

      Status: VALIDATED

      Source sequence(s)
      AC140349, AC142263
      Consensus CDS
      CCDS36580.1
      UniProtKB/Swiss-Prot
      Q0VBD0
      Related
      ENSMUSP00000026360.9, ENSMUST00000026360.9
      Conserved Domains (2) summary
      smart00187
      Location:54469
      INB; Integrin beta subunits (N-terminal portion of extracellular region)
      NF033759
      Location:470642
      exchanger_TraA; outer membrane exchange protein TraA

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      119121757..119202891 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036157503.1XP_036013396.1  integrin beta-8 isoform X1

      Conserved Domains (2) summary
      NF033759
      Location:335507
      exchanger_TraA; outer membrane exchange protein TraA
      cl00057
      Location:1334
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...