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    Mmp24 matrix metallopeptidase 24 [ Mus musculus (house mouse) ]

    Gene ID: 17391, updated on 9-Dec-2024

    Summary

    Official Symbol
    Mmp24provided by MGI
    Official Full Name
    matrix metallopeptidase 24provided by MGI
    Primary source
    MGI:MGI:1341867
    See related
    Ensembl:ENSMUSG00000027612 AllianceGenome:MGI:1341867
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MMP-21; MT5MMP; MTMMP5; MT5-MMP
    Summary
    This gene encodes a member of the matrix metalloproteinase family of extracellular matrix-degrading enzymes that are involved in tissue remodeling, wound repair, progression of atherosclerosis and tumor invasion. The encoded preproprotein undergoes proteolytic processing to generate a mature, zinc-dependent endopeptidase enzyme. Mice lacking the encoded protein do not develop neuropathic pain with mechanical allodynia after sciatic nerve injury, display enhanced sensitivity to noxious thermal stimuli under basal conditions, and develop hyperalgesia during inflammation. [provided by RefSeq, Feb 2016]
    Expression
    Biased expression in cerebellum adult (RPKM 41.0), CNS E18 (RPKM 28.2) and 7 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Mmp24 in Genome Data Viewer
    Location:
    2 H1; 2 77.26 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (155617262..155660286)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (155775342..155818367)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene ER degradation enhancer, mannosidase alpha-like 2 Neighboring gene STARR-positive B cell enhancer ABC_E10157 Neighboring gene STARR-seq mESC enhancer starr_06149 Neighboring gene protein C receptor, endothelial Neighboring gene predicted gene, 46772 Neighboring gene STARR-positive B cell enhancer ABC_E4512 Neighboring gene matrix metallopeptidase 24 opposite strand transcript 1 Neighboring gene eukaryotic translation initiation factor 6 Neighboring gene family with sequence similarity 83, member C

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (6) 
    • Targeted (2)  1 citation

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cadherin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables metalloendopeptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in extracellular matrix IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in trans-Golgi network membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    matrix metalloproteinase-24
    Names
    matrix metalloproteinase-21
    membrane type 5-MMP
    membrane-type matrix metalloproteinase 5

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010808.4NP_034938.3  matrix metalloproteinase-24 preproprotein

      See identical proteins and their annotated locations for NP_034938.3

      Status: REVIEWED

      Source sequence(s)
      AL929233, BM947491, BQ745403, CA320413, CD348827, CD355182, CF540062
      Consensus CDS
      CCDS16955.1
      UniProtKB/Swiss-Prot
      A2AUV7, Q9R0S2, Q9Z0J9
      Related
      ENSMUSP00000029141.6, ENSMUST00000029141.6
      Conserved Domains (4) summary
      cd00094
      Location:350542
      HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
      pfam00413
      Location:135300
      Peptidase_M10; Matrixin
      pfam01471
      Location:55107
      PG_binding_1; Putative peptidoglycan binding domain
      pfam11857
      Location:548618
      DUF3377; Domain of unknown function (DUF3377)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      155617262..155660286
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030248212.2XP_030104072.1  matrix metalloproteinase-24 isoform X1

      Conserved Domains (3) summary
      cd00094
      Location:350506
      HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
      pfam00413
      Location:135300
      Peptidase_M10; Matrixin
      pfam01471
      Location:55107
      PG_binding_1; Putative peptidoglycan binding domain