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    zhf1 ER zinc importer, CDF family, Zhf1 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2542060, updated on 18-Sep-2024

    Summary

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    Official Symbol
    zhf1
    Official Full Name
    ER zinc importer, CDF family, Zhf1
    Primary source
    PomBase:SPAC23C11.14
    Locus tag
    SPOM_SPAC23C11.14
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    zhf
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    Genomic context

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    See zhf1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    1
    Sequence:
    Chromosome: I; NC_003424.3 (2158307..2160086)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Clr6 histone deacetylase complex subunit Pst2 Neighboring gene ncRNA Neighboring gene Polo kinase Plo1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A transporter in the endoplasmic reticulum of Schizosaccharomyces pombe cells mediates zinc storage and differentially affects transition metal tolerance. Clemens S, et al. J Biol Chem, 2002 May 17. PMID 11886869
    2. Surplus zinc is handled by Zym1 metallothionein and Zhf endoplasmic reticulum transporter in Schizosaccharomyces pombe. Borrelly GP, et al. J Biol Chem, 2002 Aug 16. PMID 12050156
    3. Loss of Zhf and the tightly regulated zinc-uptake system SpZrt1 in Schizosaccharomyces pombe reveals the delicacy of cellular zinc balance. Boch A, et al. FEMS Yeast Res, 2008 Sep. PMID 18637840
    4. Genome-wide screen reveals novel mechanisms for regulating cobalt uptake and detoxification in fission yeast. Ryuko S, et al. Mol Genet Genomics, 2012 Aug. PMID 22806344
    5. Zinc transporters belonging to the Cation Diffusion Facilitator (CDF) family have complementary roles in transporting zinc out of the cytosol. Choi S, et al. PLoS Genet, 2018 Mar. PMID 29529046, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Zhf is involved in removal of excess of zinc from the cytosol, and together with tightly regulated Zrt1 contribute to cellular zinc homeostasis.
      Title: Loss of Zhf and the tightly regulated zinc-uptake system SpZrt1 in Schizosaccharomyces pombe reveals the delicacy of cellular zinc balance.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables zinc ion sequestering activity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables zinc ion transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in detoxification of zinc ion EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in intracellular zinc ion homeostasis EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in intracellular zinc ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular zinc ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    NOT involved_in response to zinc ion starvation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in zinc ion import into endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in zinc ion import into endoplasmic reticulum IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in zinc ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in endoplasmic reticulum membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    NOT is_active_in fungal-type vacuole membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in fungal-type vacuole membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ER zinc importer, CDF family, Zhf1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      2158307..2160086
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001019076.3 → NP_593645.1  ER zinc importer, CDF family, Zhf1 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_593645.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O13918, P78885
      Conserved Domains (2) summary
      COG1230
      Location:1 → 377
      CzcD; Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]
      pfam01545
      Location:19 → 293
      Cation_efflux; Cation efflux family
    Nucleotide Protein
    Heading Accession and Version

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