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    fkh2 DNA-binding forkhead transcription factor Fkh2 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2539703, updated on 18-Sep-2024

    Summary

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    Official Symbol
    fkh2
    Official Full Name
    DNA-binding forkhead transcription factor Fkh2
    Primary source
    PomBase:SPBC16G5.15c
    Locus tag
    SPOM_SPBC16G5.15C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See fkh2 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    2
    Sequence:
    Chromosome: II; NC_003423.3 (4239333..4242718, complement)

    Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene 40S ribosomal protein uS3 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene regulatory protein ntu1 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003423.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Deletion of the sep1(+) forkhead transcription factor homologue is not lethal but causes hyphal growth in Schizosaccharomyces pombe. Ribár B, et al. Biochem Biophys Res Commun, 1999 Sep 24. PMID 10491317
    2. The forkhead transcription factor Fkh2 regulates the cell division cycle of Schizosaccharomyces pombe. Bulmer R, et al. Eukaryot Cell, 2004 Aug. PMID 15302827, Free PMC Article
    3. Repression of meiotic genes by antisense transcription and by Fkh2 transcription factor in Schizosaccharomyces pombe. Chen HM, et al. PLoS One, 2012. PMID 22238674, Free PMC Article
    4. Characterisation of two novel fork-head gene homologues of Schizosaccharomyces pombe: their involvement in cell cycle and sexual differentiation. Szilagyi Z, et al. Gene, 2005 Mar 28. PMID 15777722
    5. Regulation of Ace2-dependent genes requires components of the PBF complex in Schizosaccharomyces pombe. Suárez MB, et al. Cell Cycle, 2015. PMID 26237280, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Fkh2 marks promoters for Mei4 binding during meiosis.
      Title: Spatiotemporal Control of Forkhead Binding to DNA Regulates the Meiotic Gene Expression Program.
    2. Fkh2 regulates not only the onset of mitotic transcription but also the correct timing of mitotic entry via effects on the Wee1 kinase
      Title: Cyclin-dependent kinase 8 regulates mitotic commitment in fission yeast.
    3. Vegetative expression of mid-meiotic genes is repressed at least two independent ways: antisense transcription and Fkh2 repression.
      Title: Repression of meiotic genes by antisense transcription and by Fkh2 transcription factor in Schizosaccharomyces pombe.
    4. activation of the Fkh2p and Sep1p forkhead transcription factors triggers mitotic gene transcription in fission yeast.
      Title: Fkh2p and Sep1p regulate mitotic gene transcription in fission yeast.
    5. Deletion of fkh2 (similar to FKH2 of S. cerevisiae) reduced the growth rate and caused an extension of cell length due to delayed G2-to-M transition.
      Title: Characterisation of two novel fork-head gene homologues of Schizosaccharomyces pombe: their involvement in cell cycle and sexual differentiation.
    6. The forkhead transcription factor Fkh2 regulates the periodic expression of cdc15+ & spo12+ in the M & G1 phases of the cell division cycle. It also regulates several cell cycle-dependent processes, including septum formation & mitotic spindle function.
      Title: The forkhead transcription factor Fkh2 regulates the cell division cycle of Schizosaccharomyces pombe.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of cell cycle switching, mitotic to meiotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of induction of conjugation with cellular fusion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of M/G1 phase-specific MADS box-forkhead transcription factor complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in chromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus HDA PubMed 
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    DNA-binding forkhead transcription factor Fkh2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003423.3 Reference assembly

      Range
      4239333..4242718 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001023784.3 → NP_596764.1  DNA-binding forkhead transcription factor Fkh2 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_596764.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O60129
      Conserved Domains (3) summary
      COG5025
      Location:6 → 622
      COG5025; Transcription factor of the Forkhead/HNF3 family [Transcription]
      cd00060
      Location:81 → 185
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      pfam00250
      Location:223 → 308
      Forkhead; Forkhead domain
    Nucleotide Protein
    Heading Accession and Version

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    Research Materials