CTP1 Ctp1p [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: CTP1
Official Full Name: Ctp1p
Primary source: SGD:S000000495
Locus tag: YBR291C
See related: AllianceGenome:SGD:S000000495; FungiDB:YBR291C; VEuPathDB:YBR291C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables tricarboxylate secondary active transmembrane transporter activity. Involved in mitochondrial citrate transmembrane transport. Located in mitochondrion. Human ortholog(s) of this gene implicated in 2-hydroxyglutaric aciduria; combined D-2- and L-2-hydroxyglutaric aciduria; and congenital myasthenic syndrome. Orthologous to human SLC25A1 (solute carrier family 25 member 1). [provided by Alliance of Genome Resources, Dec 2024]
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Chromosome II - NC_001134.8 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

Mitochondrial citrate transporters Ctp1-Yhm2 and respiratory chain: A coordinated functional connection in Saccharomyces cerevisiae metabolism.
Title: Mitochondrial citrate transporters Ctp1-Yhm2 and respiratory chain: A coordinated functional connection in Saccharomyces cerevisiae metabolism.
The present investigations examines the properties of the Gln182Cys single mutant and the Leu120Cys/Gln182Ala double mutant of the mitochondrial citrate transport protein.
Title: The mitochondrial citrate transport protein: evidence for a steric interaction between glutamine 182 and leucine 120 and its relationship to the substrate translocation pathway and identification of other mechanistically essential residues.
citrate transport protein contains at least two citrate binding sites per monomer, which are located at increasing depths within the translocation pathway
Title: Identification of the substrate binding sites within the yeast mitochondrial citrate transport protein.
determiniation of transmembrane domain residue involved in substrate translocation
Title: The yeast mitochondrial citrate transport protein: characterization of transmembrane domain III residue involvement in substrate translocation.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables citrate secondary active transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables tricarboxylate secondary active transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in mitochondrial citrate transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial citrate transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info