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    uap56 TREX complex subunit, ATP-dependent RNA helicase Uap56 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2542433, updated on 14-Nov-2024

    Summary

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    Official Symbol
    uap56
    Official Full Name
    TREX complex subunit, ATP-dependent RNA helicase Uap56
    Primary source
    PomBase:SPAC17G6.14c
    Locus tag
    SPOM_SPAC17G6.14C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See uap56 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    1
    Sequence:
    Chromosome: I; NC_003424.3 (3617071..3618875, complement)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene protein slt1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene sideroflexin Fsf1 Neighboring gene cleavage and polyadenylation specificity factor complex endoribonuclease subunit Ysh1 Neighboring gene ncRNA Neighboring gene LARP7 family RNA-binding protein Pof8/Lar7

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The nuclear export signal of splicing factor Uap56p interacts with nuclear pore-associated protein Rae1p for mRNA export in Schizosaccharomyces pombe. Thakurta AG, et al. J Biol Chem, 2007 Jun 15. PMID 17449473
    2. Multiple roles for the yeast SUB2/yUAP56 gene in splicing. Libri D, et al. Genes Dev, 2001 Jan 1. PMID 11156603, Free PMC Article
    3. A role for TREX components in the release of spliced mRNA from nuclear speckle domains. Dias AP, et al. Nat Commun, 2010 Oct 19. PMID 20981025, Free PMC Article
    4. Homolog of BRCA2-interacting Dss1p and Uap56p link Mlo3p and Rae1p for mRNA export in fission yeast. Thakurta AG, et al. EMBO J, 2005 Jul 20. PMID 15990877, Free PMC Article
    5. Red5 and three nuclear pore components are essential for efficient suppression of specific mRNAs during vegetative growth of fission yeast. Sugiyama T, et al. Nucleic Acids Res, 2013 Jul. PMID 23658229, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. When the TREX components UAP56 or Aly are knocked down, spliced mRNA, as well as total polyA+ RNA, accumulates in nuclear speckle domains.
      Title: A role for TREX components in the release of spliced mRNA from nuclear speckle domains.
    2. Data show that Uap56p interacts with Rae1p directly via its nuclear export signal, and this interaction is critical for the nuclear export activity of Uap56p as well as for exporting mRNA.
      Title: The nuclear export signal of splicing factor Uap56p interacts with nuclear pore-associated protein Rae1p for mRNA export in Schizosaccharomyces pombe.
    3. uap56 is required for mRNA transport in S. pombe
      Title: Homolog of BRCA2-interacting Dss1p and Uap56p link Mlo3p and Rae1p for mRNA export in fission yeast.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA helicase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mRNA export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus HDA PubMed 
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of transcription export complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    TREX complex subunit, ATP-dependent RNA helicase Uap56

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      3617071..3618875 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001019684.3 → NP_594261.1  TREX complex subunit, ATP-dependent RNA helicase Uap56 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_594261.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O13792, P78919
      Conserved Domains (3) summary
      PTZ00424
      Location:53 → 426
      PTZ00424; helicase 45; Provisional
      cd00079
      Location:272 → 398
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
      cd00268
      Location:53 → 257
      DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...
    Nucleotide Protein
    Heading Accession and Version

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