pmk1 MAP kinase Pmk1 [Schizosaccharomyces pombe (fission yeast)] - Gene

Summary

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Official Symbol: pmk1
Official Full Name: MAP kinase Pmk1
Primary source: PomBase:SPBC119.08
Locus tag: SPOM_SPBC119.08
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Schizosaccharomyces pombe (strain: 972h-)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
Also known as: spm1
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Genomic context

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See pmk1 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 4

Sequence:: Chromosome: II; NC_003423.3 (730816..732952)

Chromosome II - NC_003423.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003423.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

propose that the gas1-287 mutation causes longevity as the similar mechanism as cell wall stress depending on Pmk1 and Sty1 MAPK pathways
Title: gas1 mutation extends chronological lifespan via Pmk1 and Sty1 MAPKs in Schizosaccharomyces pombe.
Threonine-monophosphorylated Pmk1 was able to execute most of the biological functions of the dually phosphorylated kinase.
Title: Distinct biological activity of threonine monophosphorylated MAPK isoforms during the stress response in fission yeast.
T842 phosphorylation is not essential for Pmk1 activation, and putative phosphorylation at T846 might play an additional role in Pck2 catalytic activation and downstream signaling
Title: Multiple layers of regulation influence cell integrity control by the PKC ortholog Pck2 in fission yeast.
Consistently, the phosphorylation of Pmk1 MAPK on heat shock was decreased in the cwg2-v2 mutants, and rho4- and rho5-null cells.
Title: Geranylgeranyltransferase Cwg2-Rho4/Rho5 module is implicated in the Pmk1 MAP kinase-mediated cell wall integrity pathway in fission yeast.
findings highlight the significance of glucose availability in regulation of TORC2-Gad8 and indicate a novel link between the cAMP/PKA, Pmk1/MAPK, and TORC2-Gad8 signaling
Title: Glucose activates TORC2-Gad8 protein via positive regulation of the cAMP/cAMP-dependent protein kinase A (PKA) pathway and negative regulation of the Pmk1 protein-mitogen-activated protein kinase pathway.
Data indicate that mutation of any of the two first amino acids in the IYT motif led to a failure of inactive dual-specificity MAPK phosphatases Sdp1 to trap mitogen-activated protein kinase Slt2.
Title: A conserved non-canonical docking mechanism regulates the binding of dual specificity phosphatases to cell integrity mitogen-activated protein kinases (MAPKs) in budding and fission yeasts.
down-regulation of nuclear Pmk1 by MAPK phosphatases induced by the stress activated protein kinase pathway is important for the fine modulation of extranuclear Pmk1 activity.
Title: Biological significance of nuclear localization of mitogen-activated protein kinase Pmk1 in fission yeast.
Results suggest that Activation of Atf1 is not fully dependent on Sty1 and Pmk1.
Title: A measurable activation of the bZIP transcription factor Atf1 in a fission yeast strain devoid of stress-activated and cell integrity mitogen-activated protein kinase (MAPK) activities.
Results suggest that Ecm33 gene expression is regulated by Atf1 and Mbx1, and taht Ecm33 is involved in the negative feedback regulation of Pmk1 cell integrity signaling and is linked to cellular Ca(2+) signaling.
Title: The cell surface protein gene ecm33+ is a target of the two transcription factors Atf1 and Mbx1 and negatively regulates Pmk1 MAPK cell integrity signaling in fission yeast.
Pmk1 mitogen-activated protein kinase (MAPK) directly phosphorylates Nrd1, thereby negatively regulating the binding activity of Nrd1 to Cdc4 mRNA.
Title: Role of the RNA-binding protein Nrd1 and Pmk1 mitogen-activated protein kinase in the regulation of myosin mRNA stability in fission yeast.

Submit: New GeneRIF Correction See all GeneRIFs (15)

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by PomBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables MAP kinase activity	EXP Inferred from Experiment more info	PubMed
enables MAP kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables MAP kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cell integrity MAPK cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in cell integrity MAPK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of glucose mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of mitotic cytokinesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of calcium ion import across plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of calcium-mediated signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell wall organization or biogenesis	EXP Inferred from Experiment more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	EXP Inferred from Experiment more info	PubMed
involved_in regulation of cell wall organization or biogenesis	EXP Inferred from Experiment more info	PubMed
involved_in regulation of fungal-type cell wall biogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cell division site	HDA more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytosol	HDA more info	PubMed
is_active_in mitotic spindle pole body	HDA more info	PubMed
is_active_in nucleus	HDA more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: MAP kinase Pmk1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003423.3 Reference assembly

Range

730816..732952

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001021196.3 → NP_595289.1 MAP kinase Pmk1 [Schizosaccharomyces pombe]

See identical proteins and their annotated locations for NP_595289.1

Status: PROVISIONAL

UniProtKB/Swiss-Prot

Q92398

Conserved Domains (2) summary

cd07857
Location:20 → 351

STKc_MPK1; Catalytic domain of the Serine/Threonine Kinase, Fungal Mitogen-Activated Protein Kinase MPK1

smart00220
Location:21 → 314

S_TKc; Serine/Threonine protein kinases, catalytic domain