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    bio2 biotin synthase [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2538717, updated on 18-Sep-2024

    Summary

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    Official Symbol
    bio2
    Official Full Name
    biotin synthase
    Primary source
    PomBase:SPCC1235.02
    Locus tag
    SPOM_SPCC1235.02
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    SPCC320.01c
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    Genomic context

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    See bio2 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    1
    Sequence:
    Chromosome: III; NC_003421.2 (176817..178818)

    Chromosome III - NC_003421.2Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene SMR domain-containing protein Neighboring gene ncRNA Neighboring gene FAD synthetase Nad1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003421.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cloning of Schizosaccharomyces pombe bio2 by heterologous complementation of a Saccharomyces cerevisiae mutant. Phalip V, et al. Curr Microbiol, 1999 Dec. PMID 10525840
    2. Proteomic profiling and functional characterization of post-translational modifications of the fission yeast RNA exosome. Telekawa C, et al. Nucleic Acids Res, 2018 Nov 30. PMID 30321377, Free PMC Article
    3. A non-transcriptional role for the glucocorticoid receptor in mediating the cell stress response. Ptushkina M, et al. Sci Rep, 2017 Sep 21. PMID 28935859, Free PMC Article
    4. Chromatin remodeller Fun30(Fft3) induces nucleosome disassembly to facilitate RNA polymerase II elongation. Lee J, et al. Nat Commun, 2017 Feb 20. PMID 28218250, Free PMC Article
    5. Hierarchical modularity and the evolution of genetic interactomes across species. Ryan CJ, et al. Mol Cell, 2012 Jun 8. PMID 22681890, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables 2 iron, 2 sulfur cluster binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 4 iron, 4 sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables biotin synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables biotin synthase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in biotin biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in biotin biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in mitochondrion HDA PubMed 

    General protein information

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    Preferred Names
    biotin synthase

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003421.2 Reference assembly

      Range
      176817..178818
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001022723.3 → NP_587728.1  biotin synthase [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_587728.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O59778, O60050
      Conserved Domains (3) summary
      cd01335
      Location:66 → 268
      Radical_SAM; Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster. ...
      COG0502
      Location:20 → 345
      BioB; Biotin synthase or related enzyme [Coenzyme transport and metabolism]
      pfam06968
      Location:242 → 329
      BATS; Biotin and Thiamin Synthesis associated domain
    Nucleotide Protein
    Heading Accession and Version

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