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    brc1 BRCT domain protein Brc1 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2541071, updated on 3-Dec-2024

    Summary

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    Official Symbol
    brc1
    Official Full Name
    BRCT domain protein Brc1
    Primary source
    PomBase:SPBC582.05c
    Locus tag
    SPOM_SPBC582.05C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See brc1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    3
    Sequence:
    Chromosome: II; NC_003423.3 (426160..428919, complement)

    Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene protein dsh1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene horsetail movement protein Hrs1/Mcp6 Neighboring gene ncRNA Neighboring gene 19S proteasome regulatory subunit Rpn7

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003423.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. γH2A-binding protein Brc1 affects centromere function in fission yeast. Lee SY, et al. Mol Cell Biol, 2013 Apr. PMID 23358415, Free PMC Article
    2. Rad18 is required for DNA repair and checkpoint responses in fission yeast. Verkade HM, et al. Mol Biol Cell, 1999 Sep. PMID 10473635, Free PMC Article
    3. Multi-BRCT Domain Protein Brc1 Links Rhp18/Rad18 and γH2A To Maintain Genome Stability during S Phase. Reubens MC, et al. Mol Cell Biol, 2017 Nov 15. PMID 28784724, Free PMC Article
    4. gammaH2A binds Brc1 to maintain genome integrity during S-phase. Williams JS, et al. EMBO J, 2010 Mar 17. PMID 20094029, Free PMC Article
    5. Chromatin association of the SMC5/6 complex is dependent on binding of its NSE3 subunit to DNA. Zabrady K, et al. Nucleic Acids Res, 2016 Feb 18. PMID 26446992, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Brc1 is required for the accumulation of the Smc5-Smc6 genome stability complex in foci during replication stress and for activation of the intrinsic SUMO ligase activity of the complex by collapsed replication forks.
      Title: Brc1 Promotes the Focal Accumulation and SUMO Ligase Activity of Smc5-Smc6 during Replication Stress.
    2. Results provide evidence that Brc1 provides scaffolding functions linking gammaH2A, Rhp18, and Smc5/6 complex at damaged replication forks.
      Title: Multi-BRCT Domain Protein Brc1 Links Rhp18/Rad18 and γH2A To Maintain Genome Stability during S Phase.
    3. Brc1-mediated stabilization of stalled replication forks.
      Title: γH2A-binding protein Brc1 affects centromere function in fission yeast.
    4. Cells lacking Brc1 undergo an origin recognition complex-dependent rescue of replication stress.
      Title: Brc1-dependent recovery from replication stress.
    5. Brc1 functions to promote recombination through a novel postreplication repair pathway and the structure-specific nucleases Slx1 and Mus81.
      Title: Brc1-mediated DNA repair and damage tolerance.
    6. A particular allele of smc6 (smc6-74) is suppressed by overexpression of Brc1, a six-BRCT domain protein that is required for DNA repair during S-phase.
      Title: Brc1-mediated rescue of Smc5/6 deficiency: requirement for multiple nucleases and a novel Rad18 function.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables chromatin-protein adaptor activity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA double-strand break attachment to nuclear envelope IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in double-strand break repair EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in double-strand break repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of Cul8-RING ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in chromosome, centromeric region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in chromosome, subtelomeric region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in rDNA heterochromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in site of double-strand break IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    BRCT domain protein Brc1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003423.3 Reference assembly

      Range
      426160..428919 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001431010.1 → NP_001417957.1  BRCT domain protein Brc1 [Schizosaccharomyces pombe]

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q10337
      UniProtKB/TrEMBL
      A0AAN2L3Z3
    Nucleotide Protein
    Heading Accession and Version

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