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    pds5 mitotic and meiotic cohesin loader subunit Pds5 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2541628, updated on 14-Nov-2024

    Summary

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    Official Symbol
    pds5
    Official Full Name
    mitotic and meiotic cohesin loader subunit Pds5
    Primary source
    PomBase:SPAC110.02
    Locus tag
    SPOM_SPAC110.02
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See pds5 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    1
    Sequence:
    Chromosome: I; NC_003424.3 (1911848..1915897)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene serine/threonine protein kinase Ppk1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Rho family GTPase Cdc42

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cohesin Impedes Heterochromatin Assembly in Fission Yeast Cells Lacking Pds5. Folco HD, et al. Genetics, 2019 Sep. PMID 31278118, Free PMC Article
    2. Pds5 promotes cohesin acetylation and stable cohesin-chromosome interaction. Vaur S, et al. EMBO Rep, 2012 Jun 29. PMID 22640989, Free PMC Article
    3. Meiotic cohesins modulate chromosome compaction during meiotic prophase in fission yeast. Ding DQ, et al. J Cell Biol, 2006 Aug 14. PMID 16893973, Free PMC Article
    4. Meiotic cohesin-based chromosome structure is essential for homologous chromosome pairing in Schizosaccharomyces pombe. Ding DQ, et al. Chromosoma, 2016 Jun. PMID 26511279, Free PMC Article
    5. Establishment and maintenance of sister chromatid cohesion in fission yeast by a unique mechanism. Tanaka K, et al. EMBO J, 2001 Oct 15. PMID 11598020, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Pds5 enriched throughout heterochromatin domains is required for proper maintenance of heterochromatin. This function of Pds5 requires its associated Eso1.
      Title: Cohesin Impedes Heterochromatin Assembly in Fission Yeast Cells Lacking Pds5.
    2. The authors' data identify the HIM of Pds5 as a binding motif for Haspin/Hrk1 in fission yeast. The authors' analyses also show that human PDS5B binds Haspin through the same HIM-PIM interaction module, indicating that the Haspin localization mechanism is highly conserved.
      Title: Pds5 Regulates Sister-Chromatid Cohesion and Chromosome Bi-orientation through a Conserved Protein Interaction Module.
    3. Rec8 and Pds5 play an essential role in building a platform to support the chromosome architecture necessary for the spatial alignment of homologous chromosomes.
      Title: Meiotic cohesin-based chromosome structure is essential for homologous chromosome pairing in Schizosaccharomyces pombe.
    4. Pds5 is essential for cohesin acetylation by Eso1.
      Title: Pds5 promotes cohesin acetylation and stable cohesin-chromosome interaction.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to cohesin unloader activity IC
    Inferred by Curator
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in attachment of meiotic spindle microtubules to meiosis II kinetochore IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic sister chromatid cohesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic sister chromatid cohesion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in mitotic sister chromatid cohesion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Wpl/Pds5 cohesin loading/unloading complex EXP
    Inferred from Experiment
    more info
    		 PubMed 
    located_in chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in chromosome, subtelomeric region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in mating-type region heterochromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nuclear chromosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in pericentric heterochromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    mitotic and meiotic cohesin loader subunit Pds5

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      1911848..1915897
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001018969.3 → NP_593535.1  mitotic and meiotic cohesin loader subunit Pds5 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_593535.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O94237, Q9HFF5
      Conserved Domains (1) summary
      sd00044
      Location:244 → 272
      HEAT; HEAT repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version

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