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    rpb4 DNA-directed RNA polymerase II complex subunit Rpb4 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2541011, updated on 18-Sep-2024

    Summary

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    Official Symbol
    rpb4
    Official Full Name
    DNA-directed RNA polymerase II complex subunit Rpb4
    Primary source
    PomBase:SPBC337.14
    Locus tag
    SPOM_SPBC337.14
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See rpb4 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    4
    Sequence:
    Chromosome: II; NC_003423.3 (1055509..1056502)

    Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Gtr1/RagA G protein Gtr1 Neighboring gene ubiquinone biosynthesis protein Coq7 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene putative phosphatidyl-N-methylethanolamine N-methyltransferase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003423.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The fission yeast Rpb4 subunit of RNA polymerase II plays a specialized role in cell separation. Sharma N, et al. Mol Genet Genomics, 2006 Dec. PMID 16972065, Free PMC Article
    2. The Med8 mediator subunit interacts with the Rpb4 subunit of RNA polymerase II and Ace2 transcriptional activator in Schizosaccharomyces pombe. Mehta S, et al. FEBS Lett, 2009 Oct 6. PMID 19720063
    3. The Rpb4 subunit of fission yeast Schizosaccharomyces pombe RNA polymerase II is essential for cell viability and similar in structure to the corresponding subunits of higher eukaryotes. Sakurai H, et al. Mol Cell Biol, 1999 Nov. PMID 10523639, Free PMC Article
    4. Histone H3K36 trimethylation is essential for multiple silencing mechanisms in fission yeast. Suzuki S, et al. Nucleic Acids Res, 2016 May 19. PMID 26792892, Free PMC Article
    5. Elongation/Termination Factor Exchange Mediated by PP1 Phosphatase Orchestrates Transcription Termination. Kecman T, et al. Cell Rep, 2018 Oct 2. PMID 30282034, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Med8 mediator subunit is involved in transmitting regulatory information from Ace2 to RNA polymerase II via Rpb4.
      Title: The Med8 mediator subunit interacts with the Rpb4 subunit of RNA polymerase II and Ace2 transcriptional activator in Schizosaccharomyces pombe.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    contributes_to DNA-directed 5'-3' RNA polymerase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables translation initiation factor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transcription initiation at RNA polymerase II promoter IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of RNA polymerase II, core complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of RNA polymerase II, core complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of RNA polymerase II, holoenzyme EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    DNA-directed RNA polymerase II complex subunit Rpb4

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003423.3 Reference assembly

      Range
      1055509..1056502
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001021322.3 → NP_595415.1  DNA-directed RNA polymerase II complex subunit Rpb4 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_595415.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O74825
      Conserved Domains (1) summary
      COG5250
      Location:1 → 134
      RPB4; RNA polymerase II, fourth largest subunit [Transcription]
    Nucleotide Protein
    Heading Accession and Version

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