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    tsc2 Rheb GAP, tuberin Tsc2 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2543339, updated on 18-Sep-2024

    Summary

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    Official Symbol
    tsc2
    Official Full Name
    Rheb GAP, tuberin Tsc2
    Primary source
    PomBase:SPAC630.13c
    Locus tag
    SPOM_SPAC630.13C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See tsc2 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    1
    Sequence:
    Chromosome: I; NC_003424.3 (369791..374131, complement)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene lipid phosphatase Neighboring gene protein Vps55 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene transcriptional corepressor Tup12 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Tsc1+ and tsc2+ regulate arginine uptake and metabolism in Schizosaccharomyces pombe. van Slegtenhorst M, et al. J Biol Chem, 2004 Mar 26. PMID 14718525
    2. Constitutive Tor2 Activity Promotes Retention of the Amino Acid Transporter Agp3 at Trans-Golgi/Endosomes in Fission Yeast. Liu Q, et al. PLoS One, 2015. PMID 26447710, Free PMC Article
    3. Identification of novel single amino acid changes that result in hyperactivation of the unique GTPase, Rheb, in fission yeast. Urano J, et al. Mol Microbiol, 2005 Nov. PMID 16262791
    4. The Tsc/Rheb signaling pathway controls basic amino acid uptake via the Cat1 permease in fission yeast. Aspuria PJ, et al. Mol Genet Genomics, 2008 May. PMID 18219492, Free PMC Article
    5. Pas1, a G1 cyclin, regulates amino acid uptake and rescues a delay in G1 arrest in Tsc1 and Tsc2 mutants in Schizosaccharomyces pombe. van Slegtenhorst M, et al. Hum Mol Genet, 2005 Oct 1. PMID 16115814

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Our data reveal that both Npr2 and Tsc2 negatively regulate TORC1 signaling, and Npr2, but not Tsc2, may be involved in the feedback loop of a nutrient-sensing pathway.
      Title: TORC1 signaling is governed by two negative regulators in fission yeast.
    2. A crucial link between Tsc/Rheb signaling and the regulation of the basic amino acid permease in fission yeast.
      Title: The Tsc/Rheb signaling pathway controls basic amino acid uptake via the Cat1 permease in fission yeast.
    3. Birt-Hogg-Dube and tuberous sclerosis complex homologs have opposing roles in amino acid homeostasis in Schizosaccharomyces pombe
      Title: The Birt-Hogg-Dube and tuberous sclerosis complex homologs have opposing roles in amino acid homeostasis in Schizosaccharomyces pombe.
    4. The genome of Schizosaccharomyces pombe contains tsc1(+) and tsc2(+), homologs of human Tsc1 and Tsc2, respectively. Deletion of either tsc1(+) or tsc2(+) affects gene induction upon nitrogen starvation.
      Title: A defect in protein farnesylation suppresses a loss of Schizosaccharomyces pombe tsc2+, a homolog of the human gene predisposing to tuberous sclerosis complex.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activator activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of G1/S transition of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of TOR signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of TORC1 signaling IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of TORC1 signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of L-arginine import across plasma membrane IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of L-arginine import across plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of L-leucine import across plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of autophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of TSC1-TSC2 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of TSC1-TSC2 complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    is_active_in cytoplasm HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol HDA PubMed 
    is_active_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    Rheb GAP, tuberin Tsc2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      369791..374131 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001018309.3 → NP_592909.1  Rheb GAP, tuberin Tsc2 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_592909.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q9UUG9
      Conserved Domains (3) summary
      pfam02145
      Location:1110 → 1301
      Rap_GAP; Rap/ran-GAP
      pfam03542
      Location:699 → 924
      Tuberin; Tuberin
      pfam11864
      Location:30 → 479
      DUF3384; Domain of unknown function (DUF3384)
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

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