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    aph1 bis(5'-nucleosidyl)-tetraphosphatase [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2539292, updated on 18-Sep-2024

    Summary

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    Official Symbol
    aph1
    Official Full Name
    bis(5'-nucleosidyl)-tetraphosphatase
    Primary source
    PomBase:SPCC4G3.02
    Locus tag
    SPOM_SPCC4G3.02
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See aph1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    4
    Sequence:
    Chromosome: III; NC_003421.2 (468323..469727, complement)

    Chromosome III - NC_003421.2Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene WD40/YVTN repeat-like protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene D-3 phosphoglycerate dehydrogenase Ser3 Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003421.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Disruption and overexpression of the Schizosaccharomyces pombe aph1 gene and the effects on intracellular diadenosine 5',5'''-P1, P4-tetraphosphate (Ap4A), ATP and ADP concentrations. Ingram SW, et al. Biochem J, 2000 Sep 15. PMID 10970777, Free PMC Article
    2. Cloning of the Schizosaccharomyces pombe gene encoding diadenosine 5',5"'-P1,P4-tetraphosphate (Ap4A) asymmetrical hydrolase: sequence similarity with the histidine triad (HIT) protein family. Huang Y, et al. Biochem J, 1995 Dec 15. PMID 8554540, Free PMC Article
    3. The fission yeast FHIT homolog affects checkpoint control of proliferation and is regulated by mitochondrial electron transport. Sjölander JJ, et al. Cell Biol Int, 2020 Feb. PMID 31538680, Free PMC Article
    4. A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human. Vo TV, et al. Cell, 2016 Jan 14. PMID 26771498, Free PMC Article
    5. Hierarchical modularity and the evolution of genetic interactomes across species. Ryan CJ, et al. Mol Cell, 2012 Jun 8. PMID 22681890, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in diadenosine triphosphate catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol HDA PubMed 
    is_active_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    bis(5'-nucleosidyl)-tetraphosphatase

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003421.2 Reference assembly

      Range
      468323..469727 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001022829.3 → NP_587836.1  bis(5'-nucleosidyl)-tetraphosphatase [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_587836.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P49776
      Conserved Domains (1) summary
      cd01275
      Location:6 → 124
      FHIT; FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into ...
    Nucleotide Protein
    Heading Accession and Version

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