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    mfr1 ubiquitin ligase Mfr1 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2540043, updated on 18-Sep-2024

    Summary

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    Official Symbol
    mfr1
    Official Full Name
    ubiquitin ligase Mfr1
    Primary source
    PomBase:SPBC1198.12
    Locus tag
    SPOM_SPBC1198.12
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    fzr1; SPBC660.02
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    Genomic context

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    See mfr1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    2
    Sequence:
    Chromosome: II; NC_003423.3 (194678..195989)

    Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene asparagine--tRNA (Asn) ligase Slm5 Neighboring gene ubiquitin conjugating enzyme Ubc16 Neighboring gene ncRNA Neighboring gene RNA polymerase I transcription termination factor/ RNA polymerase II transcription factor Reb1 Neighboring gene transcription factor TFIIF complex beta subunit Tfg2 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003423.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A novel Cdc20-related WD-repeat protein, Fzr1, is required for spore formation in Schizosaccharomyces pombe. Asakawa H, et al. Mol Genet Genomics, 2001 May. PMID 11405625
    2. Cuf2 boosts the transcription of APC/C activator Fzr1 to terminate the meiotic division cycle. Aoi Y, et al. EMBO Rep, 2013 Jun. PMID 23628763, Free PMC Article
    3. The role of Schizosaccharomyces pombe dma1 in spore formation during meiosis. Krapp A, et al. J Cell Sci, 2010 Oct 1. PMID 20826461
    4. Fission yeast APC/C activators Slp1 and Fzr1 sequentially trigger two consecutive nuclear divisions during meiosis. Chikashige Y, et al. FEBS Lett, 2017 Apr. PMID 28245054
    5. Fission yeast mfr1 activates APC and coordinates meiotic nuclear division with sporulation. Blanco MA, et al. J Cell Sci, 2001 Jun. PMID 11493649

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data suggest that progression of meiosis is regulated by Slp1/Cdc20 and Fzr1/Mfr1.
      Title: Fission yeast APC/C activators Slp1 and Fzr1 sequentially trigger two consecutive nuclear divisions during meiosis.
    2. Cuf2 ensures termination of the M-phase cycle by boosting Fzr1 expression to generate functional gametes.
      Title: Cuf2 boosts the transcription of APC/C activator Fzr1 to terminate the meiotic division cycle.
    3. cell-free studies suggest that Mes1 behaves as a pseudosubstrate for Fzr1/Mfr1 but works as a competitive substrate for Slp1
      Title: Mes1 controls the meiosis I to meiosis II transition by distinctly regulating the anaphase-promoting complex/cyclosome coactivators Fzr1/Mfr1 and Slp1 in fission yeast.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables anaphase-promoting complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables anaphase-promoting complex binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin ligase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin ligase activator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in anaphase-promoting complex-dependent catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in anaphase-promoting complex-dependent catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in anaphase-promoting complex-dependent catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in metaphase/anaphase transition of meiosis II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of anaphase-promoting complex-dependent catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of ascospore formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of meiotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of anaphase-promoting complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ubiquitin ligase Mfr1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003423.3 Reference assembly

      Range
      194678..195989
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001020987.1 → NP_595081.1  ubiquitin ligase Mfr1 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_595081.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O94423
      Conserved Domains (3) summary
      COG2319
      Location:134 → 414
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:169 → 206
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:135 → 407
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    Nucleotide Protein
    Heading Accession and Version

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