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    arb1 argonaute inhibitor protein 1 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2542862, updated on 18-Sep-2024

    Summary

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    Official Symbol
    arb1
    Official Full Name
    argonaute inhibitor protein 1
    Primary source
    PomBase:SPAC140.03
    Locus tag
    SPOM_SPAC140.03
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    csp12
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    Genomic context

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    See arb1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    5
    Sequence:
    Chromosome: I; NC_003424.3 (1899966..1901605)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene succinate dehydrogenase iron-sulfur subunit protein Neighboring gene ncRNA Neighboring gene nucleolin Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene protein ctr1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Two different Argonaute complexes are required for siRNA generation and heterochromatin assembly in fission yeast. Buker SM, et al. Nat Struct Mol Biol, 2007 Mar. PMID 17310250
    2. Small-RNA loading licenses Argonaute for assembly into a transcriptional silencing complex. Holoch D, et al. Nat Struct Mol Biol, 2015 Apr. PMID 25730778, Free PMC Article
    3. RNAi-dependent heterochromatin assembly in fission yeast Schizosaccharomyces pombe requires heat-shock molecular chaperones Hsp90 and Mas5. Okazaki K, et al. Epigenetics Chromatin, 2018 Jun 4. PMID 29866182, Free PMC Article
    4. RNA interference regulates the cell cycle checkpoint through the RNA export factor, Ptr1, in fission yeast. Iida T, et al. Biochem Biophys Res Commun, 2012 Oct 12. PMID 22989756
    5. Argonaute and Triman generate dicer-independent priRNAs and mature siRNAs to initiate heterochromatin formation. Marasovic M, et al. Mol Cell, 2013 Oct 24. PMID 24095277

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables endoribonuclease inhibitor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ribonuclease inhibitor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in siRNA-mediated pericentric heterochromatin formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of ARC complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytosol HDA PubMed 
    is_active_in nucleus HDA PubMed 
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT is_active_in pericentric heterochromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    argonaute inhibitor protein 1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      1899966..1901605
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001018966.3 → NP_593532.1  argonaute inhibitor protein 1 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_593532.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q9P7B8
      Conserved Domains (1) summary
      pfam09692
      Location:32 → 399
      Arb1; Argonaute siRNA chaperone (ARC) complex subunit Arb1
    Nucleotide Protein
    Heading Accession and Version

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