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    sim3 CENP-A chaperone, NASP family, Sim3 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2540895, updated on 18-Sep-2024

    Summary

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    Official Symbol
    sim3
    Official Full Name
    CENP-A chaperone, NASP family, Sim3
    Primary source
    PomBase:SPBC577.15c
    Locus tag
    SPOM_SPBC577.15C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See sim3 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_003423.3 (780599..782483, complement)

    Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene inositol-1,4,5-trisphosphate 5-phosphatase 2 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ornithine decarboxylase antizyme spa1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene 5S ribosomal RNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003423.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Sim3 shares some common roles with the histone chaperone Asf1 in fission yeast. Tanae K, et al. FEBS Lett, 2012 Nov 30. PMID 23089178
    2. N-Terminus Does Not Govern Protein Turnover of Schizosaccharomyces pombe CENP-A. Tan HL, et al. Int J Mol Sci, 2020 Aug 26. PMID 32859127, Free PMC Article
    3. A NASP (N1/N2)-related protein, Sim3, binds CENP-A and is required for its deposition at fission yeast centromeres. Dunleavy EM, et al. Mol Cell, 2007 Dec 28. PMID 18158900, Free PMC Article
    4. Prolyl isomerization of the CENP-A N-terminus regulates centromeric integrity in fission yeast. Tan HL, et al. Nucleic Acids Res, 2018 Feb 16. PMID 29194511, Free PMC Article
    5. Sim4: a novel fission yeast kinetochore protein required for centromeric silencing and chromosome segregation. Pidoux AL, et al. J Cell Biol, 2003 Apr 28. PMID 12719471, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. N-Terminus Does Not Govern Protein Turnover of Schizosaccharomyces pombe CENP-A.
      Title: N-Terminus Does Not Govern Protein Turnover of Schizosaccharomyces pombe CENP-A.
    2. CENP-A loading chaperone Sim3 requires genomic stability-regulating site within CENP-A N-terminus prolines for binding; prolyl isomerization of the CENP-A N-terminus regulates centromeric integrity in fission yeast.
      Title: Prolyl isomerization of the CENP-A N-terminus regulates centromeric integrity in fission yeast.
    3. Sim3 shares some common roles with the histone chaperone Asf1 in fission yeast.
      Title: Sim3 shares some common roles with the histone chaperone Asf1 in fission yeast.
    4. Results suggest that one function of Sim3 is to act as an escort that hands off CENP-A(Cnp1) to chromatin assembly factors, allowing its incorporation into centromeric chromatin
      Title: A NASP (N1/N2)-related protein, Sim3, binds CENP-A and is required for its deposition at fission yeast centromeres.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone chaperone activity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in CENP-A containing chromatin assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in CENP-A containing chromatin assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in DNA replication-dependent chromatin assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in chromatin IC
    Inferred by Curator
    more info
    		  
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    CENP-A chaperone, NASP family, Sim3

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003423.3 Reference assembly

      Range
      780599..782483 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001021220.3 → NP_595313.1  CENP-A chaperone, NASP family, Sim3 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_595313.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q9USQ4
      Conserved Domains (1) summary
      pfam10516
      Location:199 → 236
      SHNi-TPR; SHNi-TPR
    Nucleotide Protein
    Heading Accession and Version

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