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    spt7 SAGA complex bromodomain subunit Spt7 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2540408, updated on 18-Sep-2024

    Summary

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    Official Symbol
    spt7
    Official Full Name
    SAGA complex bromodomain subunit Spt7
    Primary source
    PomBase:SPBC25H2.11c
    Locus tag
    SPOM_SPBC25H2.11C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See spt7 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    9
    Sequence:
    Chromosome: II; NC_003423.3 (3263270..3266875)

    Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene DNA polymerase epsilon catalytic subunit Pol2 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene chaperonin-containing T-complex eta subunit Cct7 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene tRNA acetyltransferase Neighboring gene protein Mic19

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003423.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. TOR complex 2 contributes to regulation of gene expression via inhibiting Gcn5 recruitment to subtelomeric and DNA replication stress genes. Cohen A, et al. PLoS Genet, 2022 Feb. PMID 35157728, Free PMC Article
    2. Anti-silencing factor Epe1 associates with SAGA to regulate transcription within heterochromatin. Bao K, et al. Genes Dev, 2019 Jan 1. PMID 30573453, Free PMC Article
    3. Mitotic spindle formation in the absence of Polo kinase. Kim J, et al. Proc Natl Acad Sci U S A, 2022 Mar 22. PMID 35286199, Free PMC Article
    4. The S. pombe SAGA complex controls the switch from proliferation to sexual differentiation through the opposing roles of its subunits Gcn5 and Spt8. Helmlinger D, et al. Genes Dev, 2008 Nov 15. PMID 19056896, Free PMC Article
    5. Tra1 has specific regulatory roles, rather than global functions, within the SAGA co-activator complex. Helmlinger D, et al. EMBO J, 2011 Jun 3. PMID 21642955, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables structural molecule activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to transcription coactivator activity IC
    Inferred by Curator
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transcription initiation-coupled chromatin remodeling IC
    Inferred by Curator
    more info
    		  
    Component Evidence Code Pubs
    part_of SAGA complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of SAGA complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of SAGA complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    is_active_in chromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus HDA PubMed 
    is_active_in pericentric heterochromatin EXP
    Inferred from Experiment
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    SAGA complex bromodomain subunit Spt7

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003423.3 Reference assembly

      Range
      3263270..3266875
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001022276.3 → NP_596356.2  SAGA complex bromodomain subunit Spt7 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_596356.2

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P87152
      Conserved Domains (3) summary
      cd05510
      Location:309 → 420
      Bromo_SPT7_like; Bromodomain; SPT7_like subfamily. SPT7 is a yeast protein that functions as a component of the transcription regulatory histone acetylation (HAT) complexes SAGA, SALSA, and SLIK. SAGA is involved in the RNA polymerase II-dependent transcriptional ...
      COG5076
      Location:161 → 554
      COG5076; Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]
      pfam07524
      Location:707 → 783
      Bromo_TP; Bromodomain associated
    Nucleotide Protein
    Heading Accession and Version

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