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    ubc13 ubiquitin-conjugating enzyme Ubc13 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2542925, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ubc13
    Official Full Name
    ubiquitin-conjugating enzyme Ubc13
    Primary source
    PomBase:SPAC11E3.04c
    Locus tag
    SPOM_SPAC11E3.04C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    spu13; sst5
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    Genomic context

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    See ubc13 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    4
    Sequence:
    Chromosome: I; NC_003424.3 (5287180..5288094, complement)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene microtubule-site clamp monopolin complex subunit Csm1/Pcs1 Neighboring gene ncRNA Neighboring gene SEA complex subunit Sea3 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structural and functional conservation of error-free DNA postreplication repair in Schizosaccharomyces pombe. Brown M, et al. DNA Repair (Amst), 2002 Nov 3. PMID 12531016
    2. Role of Nse1 Subunit of SMC5/6 Complex as a Ubiquitin Ligase. Kolesar P, et al. Cells, 2022 Jan 4. PMID 35011726, Free PMC Article
    3. Ubiquitin-proteasome genes as targets for modulation of cisplatin sensitivity in fission yeast. Gatti L, et al. BMC Genomics, 2011 Jan 19. PMID 21247416, Free PMC Article
    4. Histone H3G34R mutation causes replication stress, homologous recombination defects and genomic instability in S. pombe. Yadav RK, et al. Elife, 2017 Jul 18. PMID 28718400, Free PMC Article
    5. Isolation of suppressor mutants of phosphatidylinositol 3-phosphate 5-kinase deficient cells in Schizosaccharomyces pombe. Onishi M, et al. Biosci Biotechnol Biochem, 2003 Aug. PMID 12951513

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data show that ubc13 mutants exhibiting hypersensitivity to cisplatin.
      Title: Ubiquitin-proteasome genes as targets for modulation of cisplatin sensitivity in fission yeast.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin conjugating enzyme activity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables ubiquitin conjugating enzyme activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin conjugating enzyme activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ubiquitin protein ligase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in UV-damage excision repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cytoplasm to vacuole targeting by the NVT pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in postreplication repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in postreplication repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein K63-linked ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol HDA PubMed 
    is_active_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ubiquitin-conjugating enzyme Ubc13

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      5287180..5288094 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001020360.3 → NP_594929.1  ubiquitin-conjugating enzyme Ubc13 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_594929.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O13685
      Conserved Domains (2) summary
      COG5078
      Location:4 → 148
      COG5078; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
      cl00154
      Location:1 → 148
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
    Nucleotide Protein
    Heading Accession and Version

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