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    tps1 alpha,alpha-trehalose-phosphate synthase (UDP-forming) [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2542660, updated on 18-Sep-2024

    Summary

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    Official Symbol
    tps1
    Official Full Name
    alpha,alpha-trehalose-phosphate synthase (UDP-forming)
    Primary source
    PomBase:SPAC328.03
    Locus tag
    SPOM_SPAC328.03
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See tps1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    1
    Sequence:
    Chromosome: I; NC_003424.3 (3479149..3481305)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ubiquitin-protein ligase Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene AAA domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Trehalose-6-P synthase is dispensable for growth on glucose but not for spore germination in Schizosaccharomyces pombe. Blázquez MA, et al. J Bacteriol, 1994 Jul. PMID 8021171, Free PMC Article
    2. Trehalose synthesis is important for the acquisition of thermotolerance in Schizosaccharomyces pombe. Ribeiro MJ, et al. Mol Microbiol, 1997 Aug. PMID 9302019
    3. Trehalose-6P synthase is essential for trehalase activation triggered by glucose, nitrogen source or heat shock, but not by osmostress, in Schizosaccharomyces pombe. Cansado J, et al. Biochim Biophys Acta, 1998 Aug 24. PMID 9729425
    4. Accumulation of trehalose by overexpression of tps1, coding for trehalose-6-phosphate synthase, causes increased resistance to multiple stresses in the fission yeast schizosaccharomyces pombe. Soto T, et al. Appl Environ Microbiol, 1999 May. PMID 10223994, Free PMC Article
    5. Functional characterization of Schizosaccharomyces pombe neutral trehalase altered in phosphorylatable serine residues. Franco A, et al. Arch Microbiol, 2005 Sep. PMID 15965643

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Lipids and Trehalose Actively Cooperate in Heat Stress Management of Schizosaccharomyces pombe.
      Title: Lipids and Trehalose Actively Cooperate in Heat Stress Management of Schizosaccharomyces pombe.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in ascospore formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular response to heat IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in trehalose biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in trehalose biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in trehalose metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in trehalose metabolism in response to stress IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in trehalose metabolism in response to stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of alpha,alpha-trehalose-phosphate synthase complex (UDP-forming) IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of alpha,alpha-trehalose-phosphate synthase complex (UDP-forming) IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytosol HDA PubMed 

    General protein information

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    Preferred Names
    alpha,alpha-trehalose-phosphate synthase (UDP-forming)

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      3479149..3481305
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001019628.3 → NP_594205.1  alpha,alpha-trehalose-phosphate synthase (UDP-forming) [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_594205.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P40387, Q9P3U3
      Conserved Domains (2) summary
      cd03788
      Location:20 → 482
      GT1_TPS; Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a ...
      TIGR02400
      Location:20 → 483
      trehalose_OtsA; alpha,alpha-trehalose-phosphate synthase [UDP-forming]
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

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    Molecular Biology Databases
    Research Materials