DIB1 U4/U6-U5 snRNP complex subunit DIB1 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: DIB1
Official Full Name: U4/U6-U5 snRNP complex subunit DIB1
Primary source: SGD:S000006286
Locus tag: YPR082C
See related: AllianceGenome:SGD:S000006286; FungiDB:YPR082C; VEuPathDB:YPR082C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: SNU16
Summary: Involved in mRNA splicing, via spliceosome. Part of U4/U6 x U5 tri-snRNP complex and U5 snRNP. Used to study Burn-McKeown syndrome and cancer. Human ortholog(s) of this gene implicated in Burn-McKeown syndrome. Orthologous to human TXNL4A (thioredoxin like 4A). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See DIB1 in Genome Data Viewer

Location:: chromosome: XVI

Exon count:: 1

Sequence:: Chromosome: XVI; NC_001148.4 (704225..704656, complement)

Chromosome XVI - NC_001148.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data indicate that Dib1 is a robust protein that tolerates incorporation of many mutations, even at positions thought to be key for its folding stability. Further results provide mechanistic insight into how Dib1 prevents premature spliceosome activation in S. cerevisiae.
Title: Functional and Biochemical Characterization of Dib1's Role in Pre-Messenger RNA Splicing.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in RNA splicing	IEA Inferred from Electronic Annotation more info
involved_in mRNA processing	IEA Inferred from Electronic Annotation more info
involved_in mRNA splicing, via spliceosome	IEA Inferred from Electronic Annotation more info
involved_in mRNA splicing, via spliceosome	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of U4/U6 x U5 tri-snRNP complex	IBA Inferred from Biological aspect of Ancestor more info
part_of U4/U6 x U5 tri-snRNP complex	IDA Inferred from Direct Assay more info	PubMed
part_of U4/U6 x U5 tri-snRNP complex	IEA Inferred from Electronic Annotation more info
part_of U5 snRNP	IBA Inferred from Biological aspect of Ancestor more info
part_of U5 snRNP	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of spliceosomal complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: U4/U6-U5 snRNP complex subunit DIB1

NP_015407.1

17-kDa component of the U4/U6aU5 tri-snRNP; plays an essential role in pre-mRNA splicing; human ortholog TXNL4A (the human U5-specific 15-kDa protein) complements yeast dib1 null mutant

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001148.4 Reference assembly

Range

704225..704656 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001184179.1 → NP_015407.1 TPA: U4/U6-U5 snRNP complex subunit DIB1 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_015407.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W484, Q06819

UniProtKB/TrEMBL

A6ZWW7, B3LK52, C7GPS5, N1NW30

Conserved Domains (1) summary

pfam02966
Location:5 → 137

DIM1; Mitosis protein DIM1