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    gef2 RhoGEF Gef2 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2543168, updated on 18-Sep-2024

    Summary

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    Official Symbol
    gef2
    Official Full Name
    RhoGEF Gef2
    Primary source
    PomBase:SPAC31A2.16
    Locus tag
    SPOM_SPAC31A2.16
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See gef2 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    4
    Sequence:
    Chromosome: I; NC_003424.3 (419942..423991)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene arrestin/PY protein 1 Neighboring gene SNARE protein Sft1 Neighboring gene WD repeat-containing protein Neighboring gene ncRNA Neighboring gene Ctf18 RFC-like complex subunit Dcc1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene proteasome core particle subunit alpha 3 Neighboring gene splicing-associated factor Dre4 Neighboring gene ncRNA Neighboring gene nuclear membrane protein Tht1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mechanistic insights into the anchorage of the contractile ring by anillin and Mid1. Sun L, et al. Dev Cell, 2015 May 26. PMID 25959226, Free PMC Article
    2. Fission yeast type 2 node proteins Blt1p and Gef2p cooperate to ensure timely completion of cytokinesis. Kwon L, et al. BMC Mol Cell Biol, 2019 Jan 24. PMID 31041892, Free PMC Article
    3. Blt1 and Mid1 provide overlapping membrane anchors to position the division plane in fission yeast. Guzman-Vendrell M, et al. Mol Cell Biol, 2013 Jan. PMID 23149940, Free PMC Article
    4. NDR Kinase Sid2 Drives Anillin-like Mid1 from the Membrane to Promote Cytokinesis and Medial Division Site Placement. Willet AH, et al. Curr Biol, 2019 Mar 18. PMID 30853434, Free PMC Article
    5. Fission yeast Nod1 is a component of cortical nodes involved in cell size control and division site placement. Jourdain I, et al. PLoS One, 2013. PMID 23349808, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Blt1p and Gef2p work in the same pathway, rather than in parallel, to localize the NDR-family kinase Sid2p and its regulatory partner Mob1p to the division site, thereby promoting timely completion of cell division.
      Title: Fission yeast type 2 node proteins Blt1p and Gef2p cooperate to ensure timely completion of cytokinesis.
    2. our data indicate that Nod1 and Gef2 function cooperatively in a protein complex to regulate fission yeast cytokinesis.
      Title: Cooperation between Rho-GEF Gef2 and its binding partner Nod1 in the regulation of fission yeast cytokinesis.
    3. Data indicate that Nod1 and Gef2 mutually recruited each other in nodes and Nod1 also assembles Gef2 in rings.
      Title: Fission yeast Nod1 is a component of cortical nodes involved in cell size control and division site placement.
    4. Gef2 localization to cortical nodes and the contractile ring depends on its last 145 residues, and the DBL-homology domain is important for its function in cytokinesis.
      Title: Roles of putative Rho-GEF Gef2 in division-site positioning and contractile-ring function in fission yeast cytokinesis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitotic cytokinesis, division site positioning IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cell division site HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol HDA PubMed 
    is_active_in medial cortical node IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in mitotic actomyosin contractile ring IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in mitotic actomyosin contractile ring, intermediate layer IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in mitotic spindle pole body HDA PubMed 

    General protein information

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    Preferred Names
    RhoGEF Gef2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      419942..423991
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001018329.3 → NP_592928.1  RhoGEF Gef2 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_592928.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q09733
      Conserved Domains (2) summary
      pfam00621
      Location:237 → 423
      RhoGEF; RhoGEF domain
      pfam17114
      Location:824 → 967
      Nod1; Gef2-related medial cortical node protein Nod1
    Nucleotide Protein
    Heading Accession and Version

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