GND1 phosphogluconate dehydrogenase (decarboxylating) GND1 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: GND1
Official Full Name: phosphogluconate dehydrogenase (decarboxylating) GND1
Primary source: SGD:S000001226
Locus tag: YHR183W
See related: AllianceGenome:SGD:S000001226; FungiDB:YHR183W; VEuPathDB:YHR183W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables phosphogluconate dehydrogenase (decarboxylating) activity. Involved in cellular response to oxidative stress and pentose-phosphate shunt, oxidative branch. Located in mitochondrion. Orthologous to human PGD (phosphogluconate dehydrogenase). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See GND1 in Genome Data Viewer

Location:: chromosome: VIII

Exon count:: 1

Sequence:: Chromosome: VIII; NC_001140.6 (470960..472429)

Chromosome VIII - NC_001140.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001140.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

co-crystallized citrate molecules, which mimic the binding mode of the substrate 6-phosphogluconate, provided us a novel strategy to design the 6PDGH inhibitors
Title: Crystal structure of Saccharomyces cerevisiae 6-phosphogluconate dehydrogenase Gnd1.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables NADP binding	IBA Inferred from Biological aspect of Ancestor more info
enables NADP binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables phosphogluconate dehydrogenase (decarboxylating) activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphogluconate dehydrogenase (decarboxylating) activity	IEA Inferred from Electronic Annotation more info
enables phosphogluconate dehydrogenase (decarboxylating) activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in D-gluconate catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in D-gluconate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in cellular response to oxidative stress	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pentose-phosphate shunt	IEA Inferred from Electronic Annotation more info
involved_in pentose-phosphate shunt, oxidative branch	IBA Inferred from Biological aspect of Ancestor more info
involved_in pentose-phosphate shunt, oxidative branch	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	HDA more info	PubMed

General protein information

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Preferred Names: phosphogluconate dehydrogenase (decarboxylating) GND1

NP_012053.3

EC 1.1.1.44

6-phosphogluconate dehydrogenase (decarboxylating); catalyzes an NADPH regenerating reaction in the pentose phosphate pathway; required for growth on D-glucono-delta-lactone and adaptation to oxidative stress; GND1 has a paralog, GND2, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001140.6 Reference assembly

Range

470960..472429

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001179314.3 → NP_012053.3 TPA: phosphogluconate dehydrogenase (decarboxylating) GND1 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_012053.3

Status: REVIEWED

UniProtKB/Swiss-Prot

D3DLD1, P38720

UniProtKB/TrEMBL

A6ZT89, B5VKB1, C7GRK5, G2WFQ6, N1P1B1

Conserved Domains (1) summary

TIGR00873
Location:4 → 477

gnd; 6-phosphogluconate dehydrogenase (decarboxylating)