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    tif308 translation initiation factor eIF3h (p40) [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2543153, updated on 18-Sep-2024

    Summary

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    Official Symbol
    tif308
    Official Full Name
    translation initiation factor eIF3h (p40)
    Primary source
    PomBase:SPAC821.05
    Locus tag
    SPOM_SPAC821.05
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    eif8; tif38
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    Genomic context

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    See tif308 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    3
    Sequence:
    Chromosome: I; NC_003424.3 (988361..989866)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene cytoplasmic poly(A) polymerase Cid13 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene mitotic and meiotic (sporulation) septin Spn2 Neighboring gene ncRNA Neighboring gene DNA-binding transcription factor Moc3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. PCI proteins eIF3e and eIF3m define distinct translation initiation factor 3 complexes. Zhou C, et al. BMC Biol, 2005 May 17. PMID 15904532, Free PMC Article
    2. Fission yeast translation initiation factor 3 subunit eIF3h is not essential for global translation initiation, but deletion of eif3h+ affects spore formation. Ray A, et al. Yeast, 2008 Nov. PMID 19061185
    3. The S. pombe translation initiation factor eIF4G is Sumoylated and associates with the SUMO protease Ulp2. Jongjitwimol J, et al. PLoS One, 2014. PMID 24818994, Free PMC Article
    4. Dephosphorylation of F-BAR protein Cdc15 modulates its conformation and stimulates its scaffolding activity at the cell division site. Roberts-Galbraith RH, et al. Mol Cell, 2010 Jul 9. PMID 20603077, Free PMC Article
    5. Nucleocytoplasmic transport in the midzone membrane domain controls yeast mitotic spindle disassembly. Lucena R, et al. J Cell Biol, 2015 May 11. PMID 25963819, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. eIF3h deletion mutants are hypersensitive to caffeine and highly defective in meiosis, producing either no spores or incomplete tetrads with a very high frequency.
      Title: Fission yeast translation initiation factor 3 subunit eIF3h is not essential for global translation initiation, but deletion of eif3h+ affects spore formation.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables deubiquitinase activity ISM
    Inferred from Sequence Model
    more info
    		  
    enables metallopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to translation initiation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in formation of cytoplasmic translation initiation complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translational initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of COP9 signalosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in cytosol HDA PubMed 
    part_of eukaryotic 43S preinitiation complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of eukaryotic 43S preinitiation complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of eukaryotic 48S preinitiation complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of eukaryotic translation initiation factor 3 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of eukaryotic translation initiation factor 3 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    translation initiation factor eIF3h (p40)

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      988361..989866
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001018556.3 → NP_593158.1  translation initiation factor eIF3h (p40) [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_593158.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q9UT48
      Conserved Domains (1) summary
      cd08065
      Location:18 → 308
      MPN_eIF3h; Mpr1p, Pad1p N-terminal (MPN) domains without catalytic isopeptidase activity, found in eIF2h
    Nucleotide Protein
    Heading Accession and Version

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