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    pfs2 mRNA cleavage and polyadenylation specificity factor complex, WD repeat protein Pfs2 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2543089, updated on 18-Sep-2024

    Summary

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    Official Symbol
    pfs2
    Official Full Name
    mRNA cleavage and polyadenylation specificity factor complex, WD repeat protein Pfs2
    Primary source
    PomBase:SPAC12G12.14c
    Locus tag
    SPOM_SPAC12G12.14C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    cin2
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    Genomic context

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    See pfs2 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    1
    Sequence:
    Chromosome: I; NC_003424.3 (319807..321825)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Sad1-interacting factor 3 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene TRAMP complex poly(A) polymerase subunit Cid14 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene NST UDP-galactose transporter

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Inactivation of the pre-mRNA cleavage and polyadenylation factor Pfs2 in fission yeast causes lethal cell cycle defects. Wang SW, et al. Mol Cell Biol, 2005 Mar. PMID 15743824, Free PMC Article
    2. The conserved protein Seb1 drives transcription termination by binding RNA polymerase II and nascent RNA. Wittmann S, et al. Nat Commun, 2017 Apr 3. PMID 28367989, Free PMC Article
    3. CPF Recruitment to Non-canonical Transcription Termination Sites Triggers Heterochromatin Assembly and Gene Silencing. Vo TV, et al. Cell Rep, 2019 Jul 2. PMID 31269446, Free PMC Article
    4. A comparative analysis of an orthologous proteomic environment in the yeasts Saccharomyces cerevisiae and Schizosaccharomyces pombe. Roguev A, et al. Mol Cell Proteomics, 2004 Feb. PMID 14617822
    5. CPF-associated phosphatase activity opposes condensin-mediated chromosome condensation. Vanoosthuyse V, et al. PLoS Genet, 2014 Jun. PMID 24945319, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Pfs2 is required for chromosome segregation and replication, and pre-mRNA cleavage and polyadenylation. [Pfs2]
      Title: Inactivation of the pre-mRNA cleavage and polyadenylation factor Pfs2 in fission yeast causes lethal cell cycle defects.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in chromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytosol HDA PubMed 
    part_of mRNA cleavage and polyadenylation specificity factor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mRNA cleavage and polyadenylation specificity factor complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT is_active_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus HDA PubMed 
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    mRNA cleavage and polyadenylation specificity factor complex, WD repeat protein Pfs2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      319807..321825
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001018284.3 → NP_592884.1  mRNA cleavage and polyadenylation specificity factor complex, WD repeat protein Pfs2 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_592884.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q9UTN4
      Conserved Domains (3) summary
      COG2319
      Location:84 → 404
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:81 → 388
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:128 → 162
      7WD40; WD40 repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version

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