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    nse1 Smc5-6 complex ubiquitin-protein ligase E3 subunit Nse1 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2539550, updated on 18-Sep-2024

    Summary

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    Official Symbol
    nse1
    Official Full Name
    Smc5-6 complex ubiquitin-protein ligase E3 subunit Nse1
    Primary source
    PomBase:SPCC550.05
    Locus tag
    SPOM_SPCC550.05
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See nse1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    2
    Sequence:
    Chromosome: III; NC_003421.2 (1193987..1196023)

    Chromosome III - NC_003421.2Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Ski complex RNA helicase Ski2 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene pig-C family GPI synthesis protein Neighboring gene ncRNA Neighboring gene protein Hsp10 Neighboring gene ncRNA Neighboring gene N-acetyltransferase Neighboring gene fatty-acid amide hydrolase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003421.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Nse1-dependent recruitment of Smc5/6 to lesion-containing loci contributes to the repair defects of mutant complexes. Tapia-Alveal C, et al. Mol Biol Cell, 2011 Dec. PMID 21976700, Free PMC Article
    2. Novel essential DNA repair proteins Nse1 and Nse2 are subunits of the fission yeast Smc5-Smc6 complex. McDonald WH, et al. J Biol Chem, 2003 Nov 14. PMID 12966087
    3. Coordination of DNA damage responses via the Smc5/Smc6 complex. Harvey SH, et al. Mol Cell Biol, 2004 Jan. PMID 14701739, Free PMC Article
    4. Role of Nse1 Subunit of SMC5/6 Complex as a Ubiquitin Ligase. Kolesar P, et al. Cells, 2022 Jan 4. PMID 35011726, Free PMC Article
    5. A role of the Nse4 kleisin and Nse1/Nse3 KITE subunits in the ATPase cycle of SMC5/6. Vondrova L, et al. Sci Rep, 2020 Jun 16. PMID 32546830, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A role of the Nse4 kleisin and Nse1/Nse3 KITE subunits in the ATPase cycle of SMC5/6.
      Title: A role of the Nse4 kleisin and Nse1/Nse3 KITE subunits in the ATPase cycle of SMC5/6.
    2. Nse1-dependent recruitment of Smc5/6 to lesion-containing loci contributes to the DNA repair
      Title: Nse1-dependent recruitment of Smc5/6 to lesion-containing loci contributes to the repair defects of mutant complexes.
    3. Nse1 RING-like motif is a protein-protein interaction domain required for Smc5-Smc6 holocomplex integrity and recruitment to, or retention at, DNA lesions
      Title: Nse1 RING-like domain supports functions of the Smc5-Smc6 holocomplex in genome stability.
    4. Nse1 and Nse2 are non-SMC subunits of the Smc5-6 DNA repair complex. They both interact with Smc5. Nse1 and Nse2 function together with Rhp51 in the homologous recombination repair of DNA double-strand breaks. They are essential proteins. [Nse1]
      Title: Novel essential DNA repair proteins Nse1 and Nse2 are subunits of the fission yeast Smc5-Smc6 complex.
    5. Nse1, Nse2, and Nse3 are crucial for meiosis. They also play an important role in mitigating the genome destabilizing effects of replication fork stalling. [Nse1]
      Title: Nse1, Nse2, and a novel subunit of the Smc5-Smc6 complex, Nse3, play a crucial role in meiosis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin protein ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ubiquitin-protein transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in double-strand break repair via homologous recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in double-strand break repair via homologous recombination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in meiosis I IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Smc5-Smc6 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Smc5-Smc6 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Smc5-6 complex ubiquitin-protein ligase E3 subunit Nse1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003421.2 Reference assembly

      Range
      1193987..1196023
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001355912.2 → NP_001343010.1  Smc5-6 complex ubiquitin-protein ligase E3 subunit Nse1 [Schizosaccharomyces pombe]

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q53EK2
      Conserved Domains (2) summary
      pfam07574
      Location:17 → 168
      SMC_Nse1; Nse1 non-SMC component of SMC5-6 complex
      cd16493
      Location:183 → 222
      RING-CH-C4HC3_NSE1; RING-CH finger, H2 subclass (C4HC3-type), found in non-structural maintenance of chromosomes element 1 homolog (NSE1) and similar proteins
    Nucleotide Protein
    Heading Accession and Version

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    Research Materials