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    trz1 3' tRNA-processing endonuclease tRNAse Z L2 Trz1 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2542457, updated on 18-Sep-2024

    Summary

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    Official Symbol
    trz1
    Official Full Name
    3' tRNA-processing endonuclease tRNAse Z L2 Trz1
    Primary source
    PomBase:SPAC1D4.10
    Locus tag
    SPOM_SPAC1D4.10
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    sptrz1
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    Genomic context

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    See trz1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    2
    Sequence:
    Chromosome: I; NC_003424.3 (653519..656657)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene phosphatidylinositol synthase (CDP-diacylglycerol--inositol 3-phosphatidyltransferase) Pis1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene DNA replication termination factor Rtf2 Neighboring gene ncRNA Neighboring gene dual-specificity Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Overexpression of Schizosaccharomyces pombe tRNA 3'-end processing enzyme Trz2 leads to an increased cellular iron level and apoptotic cell death. Shang J, et al. Fungal Genet Biol, 2019 Jan. PMID 30393157
    2. Partitioning of the nuclear and mitochondrial tRNA 3'-end processing activities between two different proteins in Schizosaccharomyces pombe. Zhang X, et al. J Biol Chem, 2013 Sep 20. PMID 23928301, Free PMC Article
    3. The fission yeast Schizosaccharomyces pombe has two distinct tRNase Z(L)s encoded by two different genes and differentially targeted to the nucleus and mitochondria. Gan X, et al. Biochem J, 2011 Apr 1. PMID 21208191
    4. Functional conservation of tRNase ZL among Saccharomyces cerevisiae, Schizosaccharomyces pombe and humans. Zhao Z, et al. Biochem J, 2009 Aug 27. PMID 19555350
    5. ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe. Matsuyama A, et al. Nat Biotechnol, 2006 Jul. PMID 16823372

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Overexpression of trz2 but not trz1 is toxic to cells. In the present work, we showed that trz2 overexpression led to apoptotic cell death, as revealed by DAPI and Annexin V-FITC staining. Overexpression of trz2 also caused a loss of mitochondrial membrane potential and an increased reactive oxygen species (ROS) formation
      Title: Overexpression of Schizosaccharomyces pombe tRNA 3'-end processing enzyme Trz2 leads to an increased cellular iron level and apoptotic cell death.
    2. characterization of SpTrz1: nuclear localization signal; catalytic activity (precursor tRNA 3'-endonucleolytic activity)
      Title: The fission yeast Schizosaccharomyces pombe has two distinct tRNase Z(L)s encoded by two different genes and differentially targeted to the nucleus and mitochondria.
    3. and trz2 are involved in nuclear and mitochondrial tRNA 3'-end processing, respectively.
      Title: Partitioning of the nuclear and mitochondrial tRNA 3'-end processing activities between two different proteins in Schizosaccharomyces pombe.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables 3'-tRNA processing endoribonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 3'-tRNA processing endoribonuclease activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 3'-tRNA processing endoribonuclease activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in tRNA 3'-end processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in nucleus HDA PubMed 
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    3' tRNA-processing endonuclease tRNAse Z L2 Trz1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      653519..656657
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001018422.3 → NP_593023.1  3' tRNA-processing endonuclease tRNAse Z L2 Trz1 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_593023.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q10155
      Conserved Domains (4) summary
      COG1234
      Location:497 → 779
      ElaC; Ribonuclease BN, tRNA processing enzyme [Translation, ribosomal structure and biogenesis]
      pfam13691
      Location:16 → 73
      Lactamase_B_4; tRNase Z endonuclease
      cd07718
      Location:500 → 711
      RNaseZ_ELAC1_ELAC2-C-term-like_MBL-fold; Ribonuclease Z ELAC1, C-terminus of ELAC2, and related proteins; MBL-fold metallo-hydrolase domain
      cl23716
      Location:266 → 328
      metallo-hydrolase-like_MBL-fold; mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain
    Nucleotide Protein
    Heading Accession and Version

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