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    GLT1 glutamate synthase (NADH) [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851383, updated on 9-Dec-2024

    Summary

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    Official Symbol
    GLT1
    Official Full Name
    glutamate synthase (NADH)
    Primary source
    SGD:S000002330
    Locus tag
    YDL171C
    See related
    AllianceGenome:SGD:S000002330; FungiDB:YDL171C; VEuPathDB:YDL171C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables glutamate synthase (NADH) activity. Involved in ammonia assimilation cycle and glutamate biosynthetic process. Located in mitochondrion. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See GLT1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (149203..155640, complement)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene D-lactate dehydrogenase Neighboring gene Par32p Neighboring gene Uga3p Neighboring gene Ugx2p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cloning of a yeast gene coding for the glutamate synthase small subunit (GUS2) by complementation of Saccharomyces cerevisiae and Escherichia coli glutamate auxotrophs. González A, et al. Mol Microbiol, 1992 Feb. PMID 1348101
    2. Isolation and characterization of a Saccharomyces cerevisiae mutant with impaired glutamate synthase activity. Folch JL, et al. J Bacteriol, 1989 Dec. PMID 2687252, Free PMC Article
    3. Physiological Effects of GLT1 Modulation in Saccharomyces cerevisiae Strains Growing on Different Nitrogen Sources. Brambilla M, et al. J Microbiol Biotechnol, 2016 Feb. PMID 26528537
    4. Saccharomyces cerevisiae has a single glutamate synthase gene coding for a plant-like high-molecular-weight polypeptide. Cogoni C, et al. J Bacteriol, 1995 Feb. PMID 7836314, Free PMC Article
    5. Over-expressing GLT1 in a gpd2Delta mutant of Saccharomyces cerevisiae to improve ethanol production. Kong QX, et al. Appl Microbiol Biotechnol, 2007 Jul. PMID 17505823

    See all (82) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Improved production of ethanol by deleting FPS1 and over-expressing GLT1 in Saccharomyces cerevisiae.
      Title: Improved production of ethanol by deleting FPS1 and over-expressing GLT1 in Saccharomyces cerevisiae.
    2. Over-expressing the GLT1 gene in the presence of a glycerolphosphate dehydrogenase deletion increases ethanol production.
      Title: Over-expressing GLT1 in a gpd2Delta mutant of Saccharomyces cerevisiae to improve ethanol production.
    3. Chromatin organization plays a major role in the bidirectional properties of the UGA3-GLT1 promoter, through the action of an upstream Abf1p-binding consensus sequence and a polydAdT(tract).
      Title: The UGA3-GLT1 intergenic region constitutes a promoter whose bidirectional nature is determined by chromatin organization in Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables 3 iron, 4 sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables FMN binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables flavin adenine dinucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glutamate synthase (NADH) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glutamate synthase (NADH) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables glutamate synthase (NADH) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glutamate synthase (NADH) activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron-sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in L-glutamate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ammonia assimilation cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ammonia assimilation cycle IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in glutamate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glutamate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glutamate biosynthetic process IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in mitochondrion HDA PubMed 
    located_in mitochondrion HDA PubMed 

    General protein information

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    Preferred Names
    glutamate synthase (NADH)
    NP_010110.1
    • NAD(+)-dependent glutamate synthase (GOGAT); synthesizes glutamate from glutamine and alpha-ketoglutarate; with Gln1p, forms the secondary pathway for glutamate biosynthesis from ammonia; expression regulated by nitrogen source; assembles into filaments as cells approach stationary phase and under cytosolic acidification and starvation conditions

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      149203..155640 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180231.1 → NP_010110.1  TPA: glutamate synthase (NADH) [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010110.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VRI0, Q12290, Q12680
      UniProtKB/TrEMBL
      C7GL18, G2WBZ3, N1P7N3
      Conserved Domains (2) summary
      TIGR01317
      Location:1640 → 2125
      GOGAT_sm_gam; glutamate synthases, NADH/NADPH, small subunit
      PRK11750
      Location:41 → 1547
      gltB; glutamate synthase subunit alpha; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12680.2

    Gene LinkOut

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