cdc23 MCM-associated protein Mcm10 [Schizosaccharomyces pombe (fission yeast)] - Gene

Summary

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Official Symbol: cdc23
Official Full Name: MCM-associated protein Mcm10
Primary source: PomBase:SPBC1347.10
Locus tag: SPOM_SPBC1347.10
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Schizosaccharomyces pombe (strain: 972h-)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
Also known as: mcm10
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Genomic context

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See cdc23 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 1

Sequence:: Chromosome: II; NC_003423.3 (4079057..4081564)

Chromosome II - NC_003423.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003423.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A novel DNA strand-specific 'imprint', installed during DNA replication at the mating-type locus (mat1), imparts competence for cell type inter-conversion to one of the two chromosome replicas; results, while confirming the ribonucleotide nature of the imprint suggest the possibility of a direct role of Mcm10/Cdc23 in installing it in cooperation with Polalpha and Swi1
Title: Role of Cdc23/Mcm10 in generating the ribonucleotide imprint at the mat1 locus in fission yeast.
Data collection at lambda = 2.69 A (4.6 keV) allowed the crystal structure determination by sulfur SAD phasing of Cdc23(Nterm), a subunit of the multimeric anaphase-promoting complex (APC/C). At this energy, Cdc23(Nterm) has an expected Bijvoet ratio<|Fanom|>/<F>of 2.2%, with 282 residues, including six cysteines and five methionine residues, and two molecules in the asymmetric unit (65.4 kDa; 12 Cys and ten Met residu...
Title: Data collection with a tailored X-ray beam size at 2.69 Å wavelength (4.6 keV): sulfur SAD phasing of Cdc23(Nterm).
The C terminus of Mcm10p synthesized RNA, but less efficiently than the full-length protein at low rNTP levels; primase activity of Mcm10p may be essential for cell viability
Title: Fission yeast Mcm10p contains primase activity.
The interaction of Mcm10p/Cdc23p with the DNA polymerase alpha-primase complex, its binding to single-stranded DNA, and its activation of the polymerase complex together contribute to its role in the elongation phase of DNA replication. [mcm10]
Title: Primer utilization by DNA polymerase alpha-primase is influenced by its interaction with Mcm10p.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by PomBase

Function	Evidence Code	Pubs
enables DNA primase activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA replication origin binding	IBA Inferred from Biological aspect of Ancestor more info
enables MCM complex binding	IPI Inferred from Physical Interaction more info	PubMed
enables double-stranded DNA binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables single-stranded DNA binding	EXP Inferred from Experiment more info	PubMed
enables single-stranded DNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in DNA replication initiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in mating-type locus imprinting	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nuclear cell cycle DNA replication initiation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in chromatin	IDA Inferred from Direct Assay more info	PubMed
is_active_in nuclear replication fork	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nuclear replication fork	IDA Inferred from Direct Assay more info	PubMed
is_active_in site of double-strand break	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: MCM-associated protein Mcm10

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003423.3 Reference assembly

Range

4079057..4081564

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001022626.3 → NP_596702.1 MCM-associated protein Mcm10 [Schizosaccharomyces pombe]

See identical proteins and their annotated locations for NP_596702.1

Status: PROVISIONAL

UniProtKB/Swiss-Prot

O42709

Conserved Domains (1) summary

pfam09329
Location:291 → 336

zf-primase; Primase zinc finger