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    cwf10 GTPase Cwf10 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2540711, updated on 18-Sep-2024

    Summary

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    Official Symbol
    cwf10
    Official Full Name
    GTPase Cwf10
    Primary source
    PomBase:SPBC215.12
    Locus tag
    SPOM_SPBC215.12
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    csp4; snu114; spef2
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    Genomic context

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    See cwf10 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    4
    Sequence:
    Chromosome: II; NC_003423.3 (4052556..4055979)

    Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene aldo/keto reductase family protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene protein Mtl3 Neighboring gene ESCRT III complex subunit Vps20

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003423.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Early splicing functions of fission yeast Prp16 and its unexpected requirement for gene Silencing is governed by intronic features. Vijayakumari D, et al. RNA Biol, 2019 Jun. PMID 30810475, Free PMC Article
    2. Splicing factors facilitate RNAi-directed silencing in fission yeast. Bayne EH, et al. Science, 2008 Oct 24. PMID 18948543, Free PMC Article
    3. Conserved protein Pir2(ARS2) mediates gene repression through cryptic introns in lncRNAs. Thillainadesan G, et al. Nat Commun, 2020 May 15. PMID 32415063, Free PMC Article
    4. Myb-related fission yeast cdc5p is a component of a 40S snRNP-containing complex and is essential for pre-mRNA splicing. McDonald WH, et al. Mol Cell Biol, 1999 Aug. PMID 10409726, Free PMC Article
    5. The spliceosome-associated protein Nrl1 suppresses homologous recombination-dependent R-loop formation in fission yeast. Aronica L, et al. Nucleic Acids Res, 2016 Feb 29. PMID 26682798, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Deleting the S. pombe Cwf10 NTE domain impairs splicing.
      Title: Structural and functional characterization of the N terminus of Schizosaccharomyces pombe Cwf10.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables GTP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables U5 snRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in mRNA cis splicing, via spliceosome EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulatory ncRNA-mediated gene silencing EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in siRNA-mediated pericentric heterochromatin formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in spliceosomal tri-snRNP complex assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of Prp19 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of U2-type catalytic step 2 spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U4/U6 x U5 tri-snRNP complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U5 snRNP IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytosol HDA PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus HDA PubMed 
    is_active_in pericentric heterochromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of post-mRNA release spliceosomal complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of spliceosomal complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    GTPase Cwf10

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003423.3 Reference assembly

      Range
      4052556..4055979
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001022612.3 → NP_596689.2  GTPase Cwf10 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_596689.2

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O94316
      Conserved Domains (2) summary
      cl30786
      Location:139 → 967
      FusA; Translation elongation factor EF-G, a GTPase [Translation, ribosomal structure and biogenesis]
      pfam16004
      Location:5 → 122
      EFTUD2; 116 kDa U5 small nuclear ribonucleoprotein component N-terminus
    Nucleotide Protein
    Heading Accession and Version

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