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    rhp18 postreplication repair E3 ubiquitin-protein ligase [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2539686, updated on 18-Sep-2024

    Summary

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    Official Symbol
    rhp18
    Official Full Name
    postreplication repair E3 ubiquitin-protein ligase
    Primary source
    PomBase:SPBC1734.06
    Locus tag
    SPOM_SPBC1734.06
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See rhp18 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_003423.3 (1070028..1072065)

    Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene mannan polymerase I complex subunit Anp1 Neighboring gene DNAJ protein Spf31 Neighboring gene TRAPP III complex subunit Trs8502 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ESCRT-0 subunit protein HSE1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003423.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Host factors that promote retrotransposon integration are similar in distantly related eukaryotes. Rai SK, et al. PLoS Genet, 2017 Dec. PMID 29232693, Free PMC Article
    2. PCNA ubiquitylation ensures timely completion of unperturbed DNA replication in fission yeast. Daigaku Y, et al. PLoS Genet, 2017 May. PMID 28481910, Free PMC Article
    3. The Schizosaccharomyces pombe rad60 gene is essential for repairing double-strand DNA breaks spontaneously occurring during replication and induced by DNA-damaging agents. Morishita T, et al. Mol Cell Biol, 2002 May. PMID 11971984, Free PMC Article
    4. Recovery from DNA damage checkpoint arrest by PP1-mediated inhibition of Chk1. den Elzen NR, et al. EMBO J, 2004 Feb 25. PMID 14765108, Free PMC Article
    5. Multi-BRCT Domain Protein Brc1 Links Rhp18/Rad18 and γH2A To Maintain Genome Stability during S Phase. Reubens MC, et al. Mol Cell Biol, 2017 Nov 15. PMID 28784724, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables single-stranded DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in interstrand cross-link repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in postreplication repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in postreplication repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein monoubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of Rad6-Rad18 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in chromatin IC
    Inferred by Curator
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    postreplication repair E3 ubiquitin-protein ligase

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003423.3 Reference assembly

      Range
      1070028..1072065
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001021331.3 → NP_595423.1  postreplication repair E3 ubiquitin-protein ligase [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_595423.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O74747
      Conserved Domains (4) summary
      smart00513
      Location:240 → 274
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      smart00734
      Location:156 → 179
      ZnF_Rad18; Rad18-like CCHC zinc finger
      COG5432
      Location:2 → 387
      RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]
      cd00162
      Location:29 → 69
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    Nucleotide Protein
    Heading Accession and Version

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