U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    PRP31 U4/U6-U5 snRNP complex subunit PRP31 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852983, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    PRP31
    Official Full Name
    U4/U6-U5 snRNP complex subunit PRP31
    Primary source
    SGD:S000003323
    Locus tag
    YGR091W
    See related
    AllianceGenome:SGD:S000003323; FungiDB:YGR091W; VEuPathDB:YGR091W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable RNA binding activity. Involved in spliceosomal snRNP assembly. Located in mitochondrion. Part of U4/U6 x U5 tri-snRNP complex. Used to study retinitis pigmentosa. Human ortholog(s) of this gene implicated in retinitis pigmentosa and retinitis pigmentosa 11. Orthologous to human PRPF31 (pre-mRNA processing factor 31). [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See PRP31 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (666341..667825)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene tRNA-Thr Neighboring gene rRNA-processing protein UTP22 Neighboring gene serine/threonine-protein kinase DBF2 Neighboring gene Drn1p

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. The PRP31 gene encodes a novel protein required for pre-mRNA splicing in Saccharomyces cerevisiae. Weidenhammer EM, et al. Nucleic Acids Res, 1996 Mar 15. PMID 8604353, Free PMC Article
    2. Prp31p promotes the association of the U4/U6 x U5 tri-snRNP with prespliceosomes to form spliceosomes in Saccharomyces cerevisiae. Weidenhammer EM, et al. Mol Cell Biol, 1997 Jul. PMID 9199293, Free PMC Article
    3. Disease mechanism for retinitis pigmentosa (RP11) caused by mutations in the splicing factor gene PRPF31. Deery EC, et al. Hum Mol Genet, 2002 Dec 1. PMID 12444105
    4. A human homolog of yeast pre-mRNA splicing gene, PRP31, underlies autosomal dominant retinitis pigmentosa on chromosome 19q13.4 (RP11). Vithana EN, et al. Mol Cell, 2001 Aug. PMID 11545739
    5. Six novel genes necessary for pre-mRNA splicing in Saccharomyces cerevisiae. Maddock JR, et al. Nucleic Acids Res, 1996 Mar 15. PMID 8604335, Free PMC Article

    See all (52) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mRNA splicing, via spliceosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in spliceosomal snRNP assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in spliceosomal snRNP assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in spliceosomal tri-snRNP complex assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of U4 snRNP IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U4/U6 x U5 tri-snRNP complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of U4/U6 x U5 tri-snRNP complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of precatalytic spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of spliceosomal complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of spliceosomal tri-snRNP complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    U4/U6-U5 snRNP complex subunit PRP31
    NP_011605.1
    • Splicing factor; component of the U4/U6-U5 snRNP complex; homologous to human PRPF31 and used to study retinitis pigmentosa

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      666341..667825
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181220.1 → NP_011605.1  TPA: U4/U6-U5 snRNP complex subunit PRP31 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011605.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VUM3, P49704, Q66R99
      UniProtKB/TrEMBL
      A6ZV73, B3LID5, C7GWX2, C8Z8Y5, N1P9W0
      Conserved Domains (2) summary
      COG1498
      Location:1 → 389
      SIK1; RNA processing factor Prp31, contains Nop domain [Translation, ribosomal structure and biogenesis]
      pfam09785
      Location:350 → 450
      Prp31_C; Prp31 C terminal domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P49704.2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools