tpx1 thioredoxin peroxidase Tpx1 [Schizosaccharomyces pombe (fission yeast)] - Gene

Summary

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Official Symbol: tpx1
Official Full Name: thioredoxin peroxidase Tpx1
Primary source: PomBase:SPCC576.03c
Locus tag: SPOM_SPCC576.03C
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Schizosaccharomyces pombe (strain: 972h-)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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Genomic context

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See tpx1 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 1

Sequence:: Chromosome: III; NC_003421.2 (2084942..2085719, complement)

Chromosome III - NC_003421.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003421.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Hemeprotein Tpx1 interacts with cell-surface heme transporter Str3 in Schizosaccharomyces pombe.
Title: Hemeprotein Tpx1 interacts with cell-surface heme transporter Str3 in Schizosaccharomyces pombe.
Tpx1 is the only enzyme with sufficient sensitivity for peroxides and cellular abundance as to control the low levels produced during aerobic growth, catalase being the next barrier of detoxification.
Title: A genetic approach to study H2O2 scavenging in fission yeast--distinct roles of peroxiredoxin and catalase.
our data establish that redox-coupling between Trx1 and the thioredoxin peroxidase activity of Tpx1 is central for initiation of appropriate responses to different levels of hydrogen peroxide in S. pombe
Title: Inactivation of a peroxiredoxin by hydrogen peroxide is critical for thioredoxin-mediated repair of oxidized proteins and cell survival.
Thioredoxin Peroxidase inhibited thermal aggregation of citrate synthase, but BCP failed to inhibit the aggregation.
Title: Distinct functional roles of peroxiredoxin isozymes and glutathione peroxidase from fission yeast, Schizosaccharomyces pombe.
Prx protein is partly responsible for maintaining low ROS level under normal and stressful growth conditions in the fission yeast
Title: Molecular cloning, characterization and regulation of a peroxiredoxin gene from Schizosaccharomyces pombe.
the carboxy-terminal extension of Tpx1 concomitantly improves H2O2 scavenging and increases susceptibility to inactivation
Title: C-terminal truncation of the peroxiredoxin Tpx1 decreases its sensitivity for hydrogen peroxide without compromising its role in signal transduction.
redox regulation of the thioredoxin peroxidase activity of Tpx1 acts as a molecular switch controlling the transcriptional response to H(2)O(2)
Title: Oxidation of a eukaryotic 2-Cys peroxiredoxin is a molecular switch controlling the transcriptional response to increasing levels of hydrogen peroxide.
The peroxiredoxin Tpx1 is an upstream activator of Pap1. Tpx1 oxidation to the cysteine-sulfinic acid constitutes a previously uncharacterized redox switch in H2O2 signaling, restricting Pap1 activation within a narrow range of H2O2 concentrations. [Tpx1]
Title: A cysteine-sulfinic acid in peroxiredoxin regulates H2O2-sensing by the antioxidant Pap1 pathway.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by PomBase

Function	Evidence Code	Pubs
enables MAP-kinase scaffold activity	EXP Inferred from Experiment more info	PubMed
enables peroxidase activity	IDA Inferred from Direct Assay more info	PubMed
enables peroxiredoxin activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-disulfide reductase activity	EXP Inferred from Experiment more info	PubMed
enables thioredoxin peroxidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables thioredoxin peroxidase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables thioredoxin-dependent peroxiredoxin activity	IDA Inferred from Direct Assay more info	PubMed
enables unfolded protein binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in cell redox homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell redox homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular detoxification of hydrogen peroxide	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hydrogen peroxide catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in hydrogen peroxide catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of p38MAPK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to oxidative stress	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytosol	HDA more info	PubMed
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	HDA more info	PubMed

General protein information

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Preferred Names: thioredoxin peroxidase Tpx1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003421.2 Reference assembly

Range

2084942..2085719 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001023421.3 → NP_588430.1 thioredoxin peroxidase Tpx1 [Schizosaccharomyces pombe]

See identical proteins and their annotated locations for NP_588430.1

Status: PROVISIONAL

UniProtKB/Swiss-Prot

O74887

Conserved Domains (2) summary

COG0450
Location:1 → 192

AhpC; Alkyl hydroperoxide reductase subunit AhpC (peroxiredoxin) [Defense mechanisms]

cd03015
Location:5 → 176

PRX_Typ2cys; Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides. ...