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    cdc3 profilin [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2543526, updated on 18-Sep-2024

    Summary

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    Official Symbol
    cdc3
    Official Full Name
    profilin
    Primary source
    PomBase:SPAC4A8.15c
    Locus tag
    SPOM_SPAC4A8.15C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See cdc3 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    3
    Sequence:
    Chromosome: I; NC_003424.3 (2578956..2579525, complement)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ribose-phosphate pyrophosphokinase Neighboring gene tRNA-Ile Neighboring gene ncRNA Neighboring gene translation initiation factor eIF3c Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Profilin binding to poly-L-proline and actin monomers along with ability to catalyze actin nucleotide exchange is required for viability of fission yeast. Lu J, et al. Mol Biol Cell, 2001 Apr. PMID 11294914, Free PMC Article
    2. The Schizosaccharomyces pombe cdc3+ gene encodes a profilin essential for cytokinesis. Balasubramanian MK, et al. J Cell Biol, 1994 Jun. PMID 8207058, Free PMC Article
    3. F-actin distribution and function during sexual differentiation in Schizosaccharomyces pombe. Petersen J, et al. J Cell Sci, 1998 Apr. PMID 9490631
    4. Regulation and targeting of the fission yeast formin cdc12p in cytokinesis. Yonetani A, et al. Mol Biol Cell, 2008 May. PMID 18305104, Free PMC Article
    5. Fission yeast profilin is tailored to facilitate actin assembly by the cytokinesis formin Cdc12. Bestul AJ, et al. Mol Biol Cell, 2015 Jan 15. PMID 25392301, Free PMC Article

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data indicate that the essential role of profilin is to specifically facilitate formin Cdc12-mediated actin assembly for cytokinesis.
      Title: Fission yeast profilin is tailored to facilitate actin assembly by the cytokinesis formin Cdc12.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables actin monomer binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables actin monomer binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables guanyl-nucleotide exchange factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in actin cortical patch organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in actin filament polymerization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cytogamy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic actomyosin contractile ring assembly IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in mitotic actomyosin contractile ring assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sequestering of actin monomers IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in actin cortical patch TAS
    Traceable Author Statement
    more info
    		 PubMed 
    is_active_in cell cortex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cell cortex of cell tip IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in mating projection tip IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in medial cortex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    profilin

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      2578956..2579525 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001019256.3 → NP_593827.1  profilin [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_593827.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P39825
      Conserved Domains (1) summary
      pfam00235
      Location:1 → 124
      Profilin
    Nucleotide Protein
    Heading Accession and Version

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