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    PCL1 Pcl1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855427, updated on 9-Dec-2024

    Summary

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    Official Symbol
    PCL1
    Official Full Name
    Pcl1p
    Primary source
    SGD:S000005233
    Locus tag
    YNL289W
    See related
    AllianceGenome:SGD:S000005233; FungiDB:YNL289W; VEuPathDB:YNL289W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    HCS26
    Summary
    Enables cyclin-dependent protein serine/threonine kinase regulator activity. Involved in positive regulation of macroautophagy; regulation of establishment or maintenance of cell polarity; and septin ring organization. Located in incipient cellular bud site and nucleus. Part of cyclin-dependent protein kinase holoenzyme complex. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See PCL1 in Genome Data Viewer
    Location:
    chromosome: XIV
    Exon count:
    1
    Sequence:
    Chromosome: XIV; NC_001146.8 (87897..88736)

    Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene Mid1p Neighboring gene replication factor C subunit 3 Neighboring gene ncRNA Neighboring gene CCR4-NOT core subunit CAF40

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001146.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Interaction of the yeast Swi4 and Swi6 cell cycle regulatory proteins in vitro. Andrews BJ, et al. Proc Natl Acad Sci U S A, 1992 Dec 15. PMID 1465410, Free PMC Article
    2. SIT4 protein phosphatase is required for the normal accumulation of SWI4, CLN1, CLN2, and HCS26 RNAs during late G1. Fernandez-Sarabia MJ, et al. Genes Dev, 1992 Dec. PMID 1334024
    3. Transcriptional activation of CLN1, CLN2, and a putative new G1 cyclin (HCS26) by SWI4, a positive regulator of G1-specific transcription. Ogas J, et al. Cell, 1991 Sep 6. PMID 1832336
    4. CDK-mediated Yku80 Phosphorylation Regulates the Balance Between Non-homologous End Joining (NHEJ) and Homologous Directed Recombination (HDR). Carballar R, et al. J Mol Biol, 2020 Dec 4. PMID 33217428
    5. The CDK Pho85 inhibits Whi7 Start repressor to promote cell cycle entry in budding yeast. Ros-Carrero C, et al. EMBO Rep, 2024 Feb. PMID 38233717, Free PMC Article

    See all (63) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables cyclin-dependent protein serine/threonine kinase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cyclin-dependent protein serine/threonine kinase regulator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables cyclin-dependent protein serine/threonine kinase regulator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of macroautophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of establishment or maintenance of cell polarity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of establishment or maintenance of cell polarity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in septin ring organization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of cyclin-dependent protein kinase holoenzyme complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cyclin-dependent protein kinase holoenzyme complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of cyclin-dependent protein kinase holoenzyme complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in incipient cellular bud site IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Pcl1p
    NP_014110.1
    • Cyclin, interacts with cyclin-dependent kinase Pho85p; member of the Pcl1,2-like subfamily, involved in the regulation of polarized growth and morphogenesis and progression through the cell cycle; is ubiquitinated by Dma1p; phosphorylation by Pho85p targets it for degradation; localizes to sites of polarized cell growth

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001146.8 Reference assembly

      Range
      87897..88736
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183127.1 → NP_014110.1  TPA: Pcl1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014110.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W0Q4, P24867
      UniProtKB/TrEMBL
      A6ZSI9, B3LPC7, B5VQC8, C7GS52, C8ZGN2, G2WLH8, N1NWW7
      Conserved Domains (1) summary
      cd20557
      Location:54 → 149
      CYCLIN_ScPCL1-like; cyclin box found in Saccharomyces cerevisiae G1/S-specific cyclin PCL1, PCL2 and similar proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P24867.1

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