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    hnt3 aprataxin-like protein [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2539198, updated on 18-Sep-2024

    Summary

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    Official Symbol
    hnt3
    Official Full Name
    aprataxin-like protein
    Primary source
    PomBase:SPCC18.09c
    Locus tag
    SPOM_SPCC18.09C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    aptx
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    Genomic context

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    See hnt3 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    2
    Sequence:
    Chromosome: III; NC_003421.2 (1970754..1973820, complement)

    Chromosome III - NC_003421.2Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene DNA-directed RNA polymerase III complex subunit Rpc53 Neighboring gene lysine--tRNA (Lys) ligase Neighboring gene ncRNA Neighboring gene pyridoxine-pyridoxal-pyridoxamine kinase Neighboring gene Set1C complex and Lid2 complex subunit, Dpy-30 domain Sdc1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003421.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. DNA3'pp5'G de-capping activity of aprataxin: effect of cap nucleoside analogs and structural basis for guanosine recognition. Chauleau M, et al. Nucleic Acids Res, 2015 Jul 13. PMID 26007660, Free PMC Article
    2. Crystal structures of aprataxin ortholog Hnt3 reveal the mechanism for reversal of 5'-adenylated DNA. Gong Y, et al. Nat Struct Mol Biol, 2011 Oct 9. PMID 21984208
    3. Structure of an aprataxin-DNA complex with insights into AOA1 neurodegenerative disease. Tumbale P, et al. Nat Struct Mol Biol, 2011 Oct 9. PMID 21984210, Free PMC Article
    4. Aprataxin resolves adenylated RNA-DNA junctions to maintain genome integrity. Tumbale P, et al. Nature, 2014 Feb 6. PMID 24362567, Free PMC Article
    5. The fission yeast nucleoporin Alm1 is required for proteasomal degradation of kinetochore components. Salas-Pino S, et al. J Cell Biol, 2017 Nov 6. PMID 28974540, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables DNA 5'-adenosine monophosphate hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA 5'-adenosine monophosphate hydrolase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-3'-diphospho-5'-guanosine diphosphatase IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GMP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables double-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables double-stranded RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanosine binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables mismatched DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mismatched DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables single-strand break-containing DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables single-strand break-containing DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables single-stranded DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables single-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables zinc ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mismatch repair IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in single strand break repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol HDA PubMed 
    is_active_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    aprataxin-like protein

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003421.2 Reference assembly

      Range
      1970754..1973820 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001023379.3 → NP_588388.1  aprataxin-like protein [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_588388.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O74859
      Conserved Domains (2) summary
      pfam01230
      Location:45 → 156
      HIT; HIT domain
      pfam16278
      Location:172 → 224
      zf-C2HE; C2HE / C2H2 / C2HC zinc-binding finger
    Nucleotide Protein
    Heading Accession and Version

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